Evidence map›Paper›PMID 26141050›Full record

ArticleFood and environmental virology2015

Hepatitis E Virus in Domestic Pigs, Wild Boars, Pig Farm Workers, and Hunters in Estonia.

Anna Ivanova, Valentina Tefanova, Irina Reshetnjak, Tatiana Kuznetsova, Julia Geller, Åke Lundkvist, Marilin Janson, Kädi Neare, Kaisa Velström, Pikka Jokelainen and 5 more

Abstract read
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In one paragraph

Article in Food and environmental virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  3. The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Pooled it
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  18. Insights into hepatitis E virus epidemiology in Croatia.World journal of gastroenterology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Anna IvanovaDepartment of Virology, National Institute for Health Development, Tallinn, Estonia. anna.ivanova@tai.ee.
Valentina TefanovaDepartment of Virology, National Institute for Health Development, Tallinn, Estonia.
Irina ReshetnjakDepartment of Virology, National Institute for Health Development, Tallinn, Estonia.
Tatiana KuznetsovaDepartment of Virology, National Institute for Health Development, Tallinn, Estonia.
Julia GellerDepartment of Virology, National Institute for Health Development, Tallinn, Estonia.
Åke LundkvistDepartment of Medical Biochemistry and Microbiology, Zoonosis Science Center (ZSC), Uppsala University, Uppsala, Sweden.
Marilin JansonDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Kädi NeareDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Kaisa VelströmDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Pikka JokelainenDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Brian LassenDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Pirje HüttDepartment of Microbiology, Faculty of Medicine, University of Tartu, Tartu, Estonia.
Tiiu SaarDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Arvo ViltropDepartment of Basic Veterinary Sciences and Population Medicine, Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu, Estonia.
Irina GolovljovaDepartment of Virology, National Institute for Health Development, Tallinn, Estonia.
Estonian University of Life Sciences · EENational Institute for Health Development · EEUppsala University · SEUniversity of Helsinki · FIUniversity of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While hepatitis E is a growing health concern in Europe, epidemiological data on hepatitis E virus (HEV) in Estonia are scarce. Along with imported HEV infections, autochthonous cases are reported from European countries. Both domestic and wild animals can be a source of human cases of this zoonosis. Here, we investigated the presence of anti-HEV antibodies and HEV RNA in domestic pigs and wild boars, as well as in pig farm workers and hunters in Estonia. Anti-HEV antibodies were detected in 234/380 (61.6%) of sera from domestic pigs and in all investigated herds, and in 81/471 (17.2%) of meat juice samples from wild boars. HEV RNA was detected by real-time PCR in 103/449 (22.9%) of fecal samples from younger domestic pigs and 13/81 (16.0%) of anti-HEV-positive wild boar samples. Analysis of sera from 67 pig farm workers and 144 hunters revealed the presence of HEV-specific IgG in 13.4 and 4.2% of the samples, respectively. No HEV RNA was detected in the human serum samples. Phylogenetic analyses of HEV sequences from domestic pigs and wild boars, based on a 245 bp fragment from the open reading frame 2 showed that all of them belonged to genotype 3. The present study demonstrates the presence of HEV in Estonian domestic pig and wild boar populations, as well as in humans who have direct regular contact with these animals. Our results suggest that HEV infections are present in Estonia and require attention.

Indexed as

Animal HusbandryAnimalsAnimals, DomesticAnimals, WildAntibodies, ViralEpidemiological MonitoringEstoniaFarmersFecesFood ContaminationFood InspectionHepatitis E virusHumansImmunoglobulin GMeatMolecular TypingAntibodies, ViralImmunoglobulin GRNA, ViralHepatitis E virusRNASeroprevalenceZoonosis

Identifiers

PMID26141050
OpenAlexW831040180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.