ReviewPulmonary pharmacology & therapeutics2015
Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity.
Review in Pulmonary pharmacology & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Internet-Based Behavioral Cough Suppression Therapy for Refractory Chronic Cough: A Randomized Controlled Trial.American journal of speech-language pathology · 2025Trial
- Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial.BMC pulmonary medicine · 2023Trial
- Traditional Chinese medicine combined with conventional Western medicine for chronic cough following respiratory infection in children: a systematic review and meta-analysis.Translational pediatrics · 2026Article
- Expert opinion and clinical practice recommendations using a modified Delphi approach for pediatric acute cough evaluation and management in India.Lung India : official organ of Indian Chest Society · 2026Article
- Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models.Lung · 2025Article
- Activation of Adenosine Triphosphate-Gated Purinergic 2 Receptor Channels by Transient Receptor Potential Vanilloid Subtype 4 in Cough Hypersensitivity.Biomolecules · 2025Article
- Neuromodulators in Acute and Chronic Cough in Children: An Update from the Literature.International journal of molecular sciences · 2024Review
- History Taking as a Diagnostic Tool in Children With Chronic Cough.Frontiers in pediatrics · 2022Review
- Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses.The Lancet. Respiratory medicine · 2021Review
- Modulation of Vagal Sensory NeuronsFrontiers in physiology · 2021Article
- The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough.Physiological research · 2020Review
- Cough Radiculopathy: Postinfectious Cough-Related Acute Lumbar Radiculopathy.Case reports in medicine · 2020Article
- Bronchiectasis and cough: An old relationship in need of renewed attention.Pulmonary pharmacology & therapeutics · 2019Review
- Managing patients with chronic cough: challenges and solutions.Therapeutics and clinical risk management · 2018Article
- An Outbreak of Peripheral Neuropathy in a Prison.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Respiratory viral infections are a common cause of acute coughing, an irritating symptom for the patient and an important mechanism of transmission for the virus. Although poorly described, the inflammatory consequences of infection likely induce coughing by chemical (inflammatory mediator) or mechanical (mucous) activation of the cough-evoking sensory nerves that innervate the airway wall. For some individuals, acute cough can evolve into a chronic condition, in which cough and aberrant airway sensations long outlast the initial viral infection. This suggests that some viruses have the capacity to induce persistent plasticity in the neural pathways mediating cough. In this brief review we present the clinical evidence of acute and chronic neural dysfunction following viral respiratory tract infections and explore possible mechanisms by which the nervous system may undergo activation, sensitization and plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.