ReviewSleep medicine reviews2016
Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies.
Review in Sleep medicine reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of sleep loss on pain-New conceptual and mechanistic avenues.Frontiers in neuroscience · 2022Pooled it
- The effect of self-administered acupressure on pain severity and sleep quality of patients with knee osteoarthritis: a randomized controlled trial.BMC complementary medicine and therapies · 2024Trial
- rTMS targeted to the secondary somatosensory cortex influences sleep in CRPS patients, as measured with the OURA ring.Brain and behavior · 2023Trial
- Experimental sleep disruption attenuates morphine analgesia: findings from a randomized trial and implications for the opioid abuse epidemic.Scientific reports · 2020Trial
- The pain alarm response - an example of how conscious awareness shapes pain perception.Scientific reports · 2019Trial
- The role of sleep and circadian rhythms in intervertebral disc degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Sleep Quality and Its Association with Health-Related Clinical Outcomes and Biomarkers Among Rural Northern Thai Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Polysomnography demonstrates worse sleep in children and adolescents with disorders of gut-brain interaction (DGBI) compared to healthy children: A case-control study.Sleep medicine · 2026Article
- Does sleep matter before surgery? The impact of preoperative sleep quality on pain and analgesic requirement after percutaneous nephrolithotomy.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Short-Term Sleep Disruption Does Not Modify Responses to Experimentally Induced Knee Pain in Healthy Individuals.European journal of pain (London, England) · 2026Article
- Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.JDR clinical and translational research · 2026Observational
- Why sleep matters in chronic pain: evidence across the lifespan.EBioMedicine · 2026Review
- Insomnia Increases Susceptibility to Sciatica: Evidence from Mendelian Randomization and Integrative Genetic Analyses.Journal of pain research · 2026Article
- Association of nociplastic pain with executive function decline in a longitudinal cohort of middle-age adults: a prospective cohort study.British journal of anaesthesia · 2025Article
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- Revealing sleep and pain reciprocity with wearables and machine learning.Communications medicine · 2025Review
- Sex and Sleep Quality Effects on the Relationship Between Sleep Disruption and Pain Sensitivity.European journal of pain (London, England) · 2025Article
- Chronic sleep deficiency and its impact on pain perception in healthy females.Journal of sleep research · 2025Article
- Poor Sleep Quality and Mood Disorders: Risk Factors of Increasing Chronic Pain in Patients with Insomnia.Nature and science of sleep · 2025Article
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2 authors.
Funding
Abstract
Sleep and pain are critical homeostatic systems that interact in a bidirectional manner. Complaints of sleep disturbance are ubiquitous among patients with chronic pain disorders, and conversely, patients with persistent insomnia symptoms commonly report suffering from chronic pain. Sleep deprivation paradigms demonstrate that partial or complete sleep loss induce hyperalgesia, possibly due to shared mechanistic pathways including neuroanatomic and molecular substrates. Further, chronic pain conditions and sleep disturbances are intertwined through comorbidities, which together cause detrimental psychological and physical consequences. This critical review examines 29 polysomnography studies to evaluate whether nonmalignant chronic pain patients, as compared to controls, show differences in objective measures of sleep continuity and sleep architecture. Whereas these controlled studies did not reveal a consistent pattern of objective sleep disturbances, alterations of sleep continuity were commonly reported. Alterations of sleep architecture such as increases in light sleep or decreases in slow-wave sleep were less commonly reported and findings were mixed and also inconsistent. Methodological flaws were identified, which complicated interpretation and limited conclusions; hence, recommendations for future research are suggested. Knowledge of abnormalities in the sleep process has implications for understanding the pathophysiology of chronic pain conditions, which might also direct the development of novel intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.