Evidence map›Paper›PMID 26140821›Full record

SynthesisBiological psychiatry2016

Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.

Michael R Irwin, Richard Olmstead, Judith E Carroll

3 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1,080 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,080citing papers in PubMed, 8 pooled it
60.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067777 phase2terminatednot on this mapstarted 2022, after this paper: background citation

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
NCT05248360 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Randomized, Double-blind, Crossover, Placebo-controlled Study to Evaluate the Efficacy and Safety of Hydrogen-oxygen Mixed Gas in the Treatment of Insomnia

TypeinterventionalSponsorSecond Affiliated Hospital of Soochow UniversityRan2022 to 2023Enrolled40ConditionsInsomniaArmsHydrogen-oxygen mixed gas(H2-O2) inhalation, Air inhalation
NCT06300684 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Sleep, Diet and Chrononutrition: Studying the Dual Effect of Cognitive Behavioral Therapy for Insomnia (CBTi) on Sleep and Dietary Habits

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2022 to 2025Enrolled40ConditionsInsomniaArmsCognitive Behavioral Therapy for Insomnia (CBT-i)
3 · Its place in the literature

Who cites it

1,080 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,938 citations in OpenAlex.

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  5. Short-term sleep benefitsFrontiers in pharmacology · 2026
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  9. Integrated psychosocial, sleep, and immunonutritional intervention improves psychological adaptation, sleep disturbance, and inflammatory activation in rectal cancer: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  13. Integrated sleep and psychological interventions enhance postoperative recovery and quality of life in colorectal cancer: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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1,020 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael R IrwinCousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, California.; Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.; Department of Psychology, University of California, Los Angeles, Los Angeles, California.. Electronic address: mirwin1@ucla.edu.
Richard OlmsteadCousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, California.; Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Judith E CarrollCousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, California.; Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · US

Funding

USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep, Inflamation, and Depression Occurrence in Breast Cancer SurvivorsR01CA160245 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2012 to 2016
$3.9M
Chronic Moderate Sleep Restriction in Older Long and Older Average SleepersR01HL095799 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI IRWIN, MICHAEL R, JEAN-LOUIS, GIRARDIN · 2011 to 2015
$3.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsR01CA119159 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2010
$2.2M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Late life sleep disturbances: Effects on cell stress, telomerase, inflammationK01AG044462 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARROLL, JUDITH E · 2013 to 2017
$633k
NCI NIH HHS R01 CA119159NCI NIH HHS R01 CA160245NCRR NIH HHS UL1 RR033176NHLBI NIH HHS R01 HL079955NHLBI NIH HHS R01 HL095799NIA NIH HHS K01 AG044462NIA NIH HHS P30 AG017265NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01 AG034588
6 · The paper itself

Abstract

backgroundSleep disturbance is associated with inflammatory disease risk and all-cause mortality. Here, we assess global evidence linking sleep disturbance, sleep duration, and inflammation in adult humans.

methodsA systematic search of English language publications was performed, with inclusion of primary research articles that characterized sleep disturbance and/or sleep duration or performed experimental sleep deprivation and assessed inflammation by levels of circulating markers. Effect sizes (ES) and 95% confidence intervals (CI) were extracted and pooled using a random effect model.

resultsA total of 72 studies (n > 50,000) were analyzed with assessment of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNFα). Sleep disturbance was associated with higher levels of CRP (ES .12; 95% CI = .05-.19) and IL-6 (ES .20; 95% CI = .08-.31). Shorter sleep duration, but not the extreme of short sleep, was associated with higher levels of CRP (ES .09; 95% CI = .01-.17) but not IL-6 (ES .03; 95% CI: -.09 to .14). The extreme of long sleep duration was associated with higher levels of CRP (ES .17; 95% CI = .01-.34) and IL-6 (ES .11; 95% CI = .02-20). Neither sleep disturbances nor sleep duration was associated with TNFα. Neither experimental sleep deprivation nor sleep restriction was associated with CRP, IL-6, or TNFα. Some heterogeneity among studies was found, but there was no evidence of publication bias.

conclusionsSleep disturbance and long sleep duration, but not short sleep duration, are associated with increases in markers of systemic inflammation.

Indexed as

AdultHumansInflammationSleepSleep DeprivationSleep Wake DisordersInflammationInsomniaInterleukin-6Meta-analysisSleep deprivationSleep disturbanceSleep duration

Identifiers

PMID26140821
PMCPMC4666828
OpenAlexW646218571

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.