Evidence map›Paper›PMID 26140740›Full record

ArticleArchives of physical medicine and rehabilitation2015

Greater Adipose Tissue Distribution and Diminished Spinal Musculoskeletal Density in Adults With Cerebral Palsy.

Mark D Peterson, Peng Zhang, Heidi J Haapala, Stewart C Wang, Edward A Hurvitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mark D PetersonDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI. Electronic address: mdpeterz@med.umich.edu.
Peng ZhangDepartment of Surgery, University of Michigan, Ann Arbor, MI; Morphomic Analysis Group, University of Michigan, Ann Arbor, MI.
Heidi J HaapalaDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI.
Stewart C WangDepartment of Surgery, University of Michigan, Ann Arbor, MI; Morphomic Analysis Group, University of Michigan, Ann Arbor, MI.
Edward A HurvitzDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI.
University of Michigan · USMorpho (United States) · US

Funding

Secondary Muscle Pathology & Metabolic Dysregulation in Adult with Cerebral PalsyK01HD074706 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, MARK D · 2013 to 2017
$605k
NICHD NIH HHS 1K01 HD074706NICHD NIH HHS K01 HD074706
6 · The paper itself

Abstract

objectivesTo examine differences in adipose tissue distribution, lumbar vertebral bone mineral density (BMD), and muscle attenuation in adults with and without cerebral palsy (CP), and to determine the associations between morphologic characteristics.

designCross-sectional, retrospective analyses of archived computed tomography scans.

settingClinical treatment and rehabilitation center.

participantsAdults (N=352) with CP (age, 38.8±14.4y; body mass, 61.3±17.1kg; Gross Motor Function Classification System levels, I-V) and a matched cohort of neurotypical adults. Of the 41 adults with CP included in the study, 10 were not matchable because of low body masses.

interventionsNot applicable.

main outcome measuresComputed tomography scans were assessed for visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas, psoas major area and attenuation in Hounsfield units (Hu), and cortical and trabecular BMDs.

resultsAdults with CP had lower cortical (β=-63.41 Hu, P<.001) and trabecular (β=-42.24 Hu, P<.001) BMDs and psoas major areas (β=-374.51mm(2), P<.001) and attenuation (β=-9.21 Hu, P<.001) after controlling for age, sex, and body mass. Adults with CP had greater VAT (β=3914.81mm(2), P<.001) and SAT (β=4615.68mm(2), P<.001). Muscle attenuation was significantly correlated with trabecular (r=.51, P=.002) and cortical (r=.46, P<.01) BMD, whereas VAT was negatively associated with cortical BMD (β=-.037 Hu/cm(2), r(2)=.13, P=.03).

conclusionsAdults with CP had lower BMDs, smaller psoas major area, greater intermuscular adipose tissue, and greater trunk adiposity than neurotypical adults. VAT and cortical BMD were inversely associated.

Indexed as

Body Fat DistributionBone DensityAdultCerebral PalsyCross-Sectional StudiesFemaleHumansLumbar VertebraeMaleMuscle, SkeletalRetrospective StudiesSarcopeniaTomography, X-Ray ComputedAdiposityBone densityCerebral palsyIntra-abdominal fatRehabilitationSarcopenia

Identifiers

PMID26140740
PMCPMC4601929
OpenAlexW1798650350

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.