Evidence map›Paper›PMID 26140718›Full record

ReviewComprehensive Physiology2015

Platelets and Their Interactions with Other Immune Cells.

Fong W Lam, K Vinod Vijayan, Rolando E Rumbaut

Open access · greenAbstract readReview
In one paragraph

Review in Comprehensive Physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Endotheliopathy in Acute COVID-19 and Long COVID.International journal of molecular sciences · 2023
    Pooled it
  2. Review
  3. Platelet subpopulations and contribution to hemostasis.Blood science (Baltimore, Md.) · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Platelet Storage-Problems, Improvements, and New Perspectives.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fong W LamCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.
K Vinod VijayanCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.
Rolando E RumbautCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, USA.
Baylor College of Medicine · USMichael E. DeBakey VA Medical Center · US

Funding

Serine/Threonine Phosphatases and Platelet PhysiologyR01HL081613 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI VIJAYAN, K. VINOD · 2006 to 2016
$3.1M
Microvascular Thrombosis in systemic inflammationR01GM112806 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI CRUZ, MIGUEL ANGEL, NGUYEN, TRUNG CHANH · 2014 to 2022
$3.0M
Platelets and Their Microparticles in the Inflamed MicrocirculationR01HL116524 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BURNS, ALAN R, RUMBAUT, ROLANDO E · 2013 to 2017
$1.8M
The complement system links platelet activation to inflammationI01BX000550 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI RUMBAUT, ROLANDO E · 2009 to 2013
–
BLRD VA I01 BX000550NHLBI NIH HHS HL081613NHLBI NIH HHS R01 HL081613NHLBI NIH HHS R01 HL116524NIGMS NIH HHS R01 GM112806PHS HHS NHLBI HL116524PHS HHS NIGMSGM112806
6 · The paper itself

Abstract

Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This article reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions.

Indexed as

AnimalsBlood PlateletsChemokinesCytokinesHumansLeukocytesThrombosisToll-Like ReceptorsChemokinesCytokinesToll-Like Receptors

Identifiers

PMID26140718
PMCPMC4510953
OpenAlexW1484715519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.