Evidence map›Paper›PMID 26140587›Full record

ArticleCell2015

From Prescription to Transcription: Genome Sequence as Drug Target.

Cong Guo, Anthony M D'Ippolito, Timothy E Reddy

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Natural human genetic variation determines basal and inducible expression ofProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cong GuoCenter for Genomic and Computational Biology, Duke University Medical School, Durham, NC 27708, USA; University Program in Genetics and Genomics, Duke University Medical School, Durham, NC 27708, USA.
Anthony M D'IppolitoCenter for Genomic and Computational Biology, Duke University Medical School, Durham, NC 27708, USA; University Program in Genetics and Genomics, Duke University Medical School, Durham, NC 27708, USA.
Timothy E ReddyCenter for Genomic and Computational Biology, Duke University Medical School, Durham, NC 27708, USA; Department of Biostatistics and Bioinformatics, Duke University Medical School, Durham, NC 27708, USA. Electronic address: tim.reddy@duke.edu.
Duke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Personalizing treatments to account for genetically mediated differences in drug responses is an exciting opportunity to improve patient outcomes. In this issue, Soccio et al. reveal new mechanisms by which non-coding variants alter the activity of the anti-diabetic drug rosiglitazone.

Indexed as

Polymorphism, Single NucleotideAnimalsHumansHypoglycemic AgentsPPAR gammaHypoglycemic AgentsPPAR gamma

Identifiers

PMID26140587
OpenAlexW1481676238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.