ArticleThe ISME journal2016
Density-dependent adaptive resistance allows swimming bacteria to colonize an antibiotic gradient.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Programmable 3D Microfluidics Reveals Motility-Driven Antibiotic Resistance Evolution in Gradients.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Aer is a bidirectional redox sensor mediating negative chemotaxis to antibiotic-induced ROS inmBio · 2026Article
- A nutrient bottleneck controls antibiotic efficacy in structured bacterial populations.Nature communications · 2026Article
- From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance.Annual review of microbiology · 2024Review
- Diversity and Antibiotic Resistance of Triticale Seed-Borne Bacteria on the Tibetan Plateau.Microorganisms · 2024Article
- Microfluidics for adaptation of microorganisms to stress: design and application.Applied microbiology and biotechnology · 2024Review
- Bacterial motility can govern the dynamics of antibiotic resistance evolution.Nature communications · 2023Article
- Chemical Characterization and Antimicrobial Properties of the Hydroalcoholic Solution ofMolecules (Basel, Switzerland) · 2023Article
- Suicidal chemotaxis in bacteria.Nature communications · 2022Article
- Ecological succession and the competition-colonization trade-off in microbial communities.BMC biology · 2022Article
- Interactions between Bacterial Inoculants and Native Soil Bacterial Community: the Case of Spore-forming Bacillus spp.FEMS microbiology ecology · 2022Article
- Efflux-linked accelerated evolution of antibiotic resistance at a population edge.Molecular cell · 2022Article
- Growth-mediated negative feedback shapes quantitative antibiotic response.Molecular systems biology · 2022Article
- Competitive interaction of thymol with cviR inhibits quorum sensing and associated biofilm formation in Chromobacterium violaceum.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- SkewDB, a comprehensive database of GC and 10 other skews for over 30,000 chromosomes and plasmids.Scientific data · 2022Article
- Emergence of ResistantFrontiers in microbiology · 2022Article
- The role of chemotaxis and efflux pumps on nitrate reduction in the toxic regions of a ciprofloxacin concentration gradient.The ISME journal · 2021Article
- Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) and Hypericum Perforatum Modifies In Situ Oral Biofilms.Scientific reports · 2019Article
- Dead bacterial absorption of antimicrobial peptides underlies collective tolerance.Journal of the Royal Society, Interface · 2019Article
- Niche and fitness differences determine invasion success and impact in laboratory bacterial communities.The ISME journal · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
During antibiotic treatment, antibiotic concentration gradients develop. Little is know regarding the effects of antibiotic gradients on populations of nonresistant bacteria. Using a microfluidic device, we show that high-density motile Escherichia coli populations composed of nonresistant bacteria can, unexpectedly, colonize environments where a lethal concentration of the antibiotic kanamycin is present. Colonizing bacteria establish an adaptively resistant population, which remains viable for over 24 h while exposed to the antibiotic. Quantitative analysis of multiple colonization events shows that collectively swimming bacteria need to exceed a critical population density in order to successfully colonize the antibiotic landscape. After colonization, bacteria are not dormant but show both growth and swimming motility under antibiotic stress. Our results highlight the importance of motility and population density in facilitating adaptive resistance, and indicate that adaptive resistance may be a first step to the emergence of genetically encoded resistance in landscapes of antibiotic gradients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.