Evidence map›Paper›PMID 26140247›Full record

ArticleOncoimmunology2015

Combined IL-15 and IL-12 drives the generation of CD34

Jeannette Cany, Anniek B van der Waart, Jan Spanholtz, Marleen Tordoir, Joop H Jansen, Robbert van der Voort, Nicolaas M Schaap, Harry Dolstra

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Good manufacturing practice production of an off-the-shelf CD34Cellular and molecular life sciences : CMLS · 2025
    Article
  4. Feeder-cell-free system forFrontiers in immunology · 2025
    Article
  5. Article
  6. CAR-NK cells derived from cord blood originate mainly from CD56Molecular therapy. Methods & clinical development · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Good manufacturing practice production of CD34Cancer immunology, immunotherapy : CII · 2023
    Article
  14. Human CD34Cellular and molecular life sciences : CMLS · 2023
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jeannette CanyDepartment of Laboratory Medicine; Laboratory of Hematology; Radboud University Medical Center (Radboudumc); Nijmegen, The Netherlands.
Anniek B van der WaartDepartment of Laboratory Medicine; Laboratory of Hematology; Radboud University Medical Center (Radboudumc); Nijmegen, The Netherlands.
Jan SpanholtzGlycostem Therapeutics; 's-Hertogenbosch , The Netherlands.
Marleen TordoirGlycostem Therapeutics; 's-Hertogenbosch , The Netherlands.
Joop H JansenDepartment of Laboratory Medicine; Laboratory of Hematology; Radboud University Medical Center (Radboudumc); Nijmegen, The Netherlands.
Robbert van der VoortDepartment of Laboratory Medicine; Laboratory of Hematology; Radboud University Medical Center (Radboudumc); Nijmegen, The Netherlands.
Nicolaas M SchaapDepartment of Hematology; Radboudumc ; Nijmegen, The Netherlands.
Harry DolstraDepartment of Laboratory Medicine; Laboratory of Hematology; Radboud University Medical Center (Radboudumc); Nijmegen, The Netherlands.
Expertise Center Vocational Education · NLRadboud University Nijmegen · NLUniversity Medical Center · USRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive transfer of allogeneic natural killer (NK) cells represents a promising treatment approach against cancer, including acute myeloid leukemia (AML). Previously, we reported a cytokine-based culture method for the generation of NK cell products with high cell number and purity. In this system, CD34

Indexed as

acute myeloid leukemiaadoptive immunotherapyAML, acute myeloid leukemiaBM, bone marrowHPC, hematopoietic progenitor cellHSCT, hematopoietic stem cell transplantationinterferon-gammainterleukin-12killer immunoglobulin-like receptorKIR, killer immunoglobulin-like receptornatural killer cellNK, natural killerNSG, NOD/SCID-IL2RγnullUCB, umbilical cord blood

Identifiers

PMID26140247
PMCPMC4485802
OpenAlexW1584836888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.