ArticleImmune network2015
Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells.
Article in Immune network, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation.Blood · 2024Article
- Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.Cell reports · 2023Article
- Single-cell biological network inference using a heterogeneous graph transformer.Nature communications · 2023Article
- Early Growth Response Factor 1 in Aging Hematopoietic Stem Cells and Leukemia.Frontiers in cell and developmental biology · 2022Review
- Global Characterization of Peripheral B Cells in Parkinson's Disease by Single-Cell RNA and BCR Sequencing.Frontiers in immunology · 2022Article
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- Epigenetic programming underpins B cell dysfunction in human SLE.Nature immunology · 2019Article
- Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis.Arthritis research & therapy · 2019Article
- Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs.PloS one · 2019Article
- Transcriptional Analysis of the Human IgE-Expressing Plasma Cell Differentiation Pathway.Frontiers in immunology · 2019Article
- Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4＋ T cells.BMB reports · 2017Article
- Genome-Wide Identification of Target Genes for the Key B Cell Transcription FactorFrontiers in immunology · 2017Article
- Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn Serum-induced Arthritis.Immune network · 2016Article
- The progress of early growth response factor 1 and leukemia.Intractable & rare diseases research · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early growth response (Egr)-1 is a Cys2-His2-type zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1 (-/-) mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1 (-/-) and WT mice. However, Egr1 (-/-) B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1 (-/-) mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells.
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