Evidence map›Paper›PMID 26139726›Full record

ArticleGenome announcements2015

Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459.

D A Maslov, K V Shur, O B Bekker, N V Zakharevich, M V Zaichikova, K M Klimina, T G Smirnova, Y Zhang, L N Chernousova, V N Danilenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome announcements, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

D A MaslovLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.ORCID http://orcid.org/0000-0003-4296-5815
K V ShurLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.
O B BekkerLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.ORCID http://orcid.org/0000-0003-2015-0025
N V ZakharevichLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.
M V ZaichikovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.
K M KliminaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.
T G SmirnovaMicrobiology Department, Central Tuberculosis Research Institute RAMS, Moscow, Russia.
Y ZhangW. Harry Feinstone Department of Molecular Microbiology & Immunology, Department of Molecular Microbiology & Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
L N ChernousovaMicrobiology Department, Central Tuberculosis Research Institute RAMS, Moscow, Russia.
V N DanilenkoLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia valerid@vigg.ru.

Funding

Pyrazinamide and Trans-Translation in Mycobacterium tuberculosisR01AI099512 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZHANG, YING · 2012 to 2015
$1.7M
Toxin-antitoxins & RpsA in TB drug resistance & persistence with HIVR21AI108535 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZHANG, YING · 2014 to 2015
$443k
NIAID NIH HHS R01 AI099512NIAID NIH HHS R21 AI108535
6 · The paper itself

Abstract

We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed unique mutations, which may elucidate new mechanisms of PZA resistance.

Identifiers

PMID26139726
PMCPMC4490854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.