Evidence map›Paper›PMID 26139426›Full record

ArticleMaturitas2015

Anti-mullerian hormone (AMH) is associated with natural menopause in a population-based sample: The CARDIA Women's Study.

Sangeeta Nair, James C Slaughter, James G Terry, Duke Appiah, Imo Ebong, Erica Wang, David S Siscovick, Barbara Sternfeld, Pamela J Schreiner, Cora E Lewis and 2 more

Abstract read
In one paragraph

Article in Maturitas, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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  20. The role of anti-Müllerian hormone (AMH) in ovarian disease and infertility.Journal of assisted reproduction and genetics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Sangeeta NairDepartment of Radiology and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University, 2525 West End Avenue, Suite 600, Nashville, TN 37203, United States.
James C SlaughterDepartment of Biostatistics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1100, Nashville, TN 37203, United States.
James G TerryDepartment of Radiology and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University, 2525 West End Avenue, Suite 600, Nashville, TN 37203, United States.
Duke AppiahDivision of Epidemiology and Community Health, University of Minnesota, 1300 S 2nd St., Suite 300, Minneapolis, MN 55454, United States.
Imo EbongLoma Linda University Medical Center Transplantation Institute, 25865 Barton Road, Suite 101, Loma Linda, CA 92354, United States.
Erica WangDepartment of Obstetrics and Gynecology, Cedars Sinai Medical Center, San Diego, CA 90048, United States.
David S SiscovickNew York Academy of Medicine, New York, NY 10029, United States.
Barbara SternfeldKaiser Permanente, Division of Research, Epidemiology and Prevention, 2000 Broadway, Oakland, CA 94612, United States.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota, 1300 S 2nd St., Suite 300, Minneapolis, MN 55454, United States.
Cora E LewisDivision of Preventive Medicine, Department of Medicine, University of Alabama Birmingham, 1717 11th Avenue South, Room 614, Birmingham, AL 35205, United States.
Edmond K KabagambeDepartment of Medicine and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University, 2525 West End Avenue, Suite 600, Nashville, TN 37203, United States.
Melissa F WellonsDepartment of Medicine and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University, 2525 West End Avenue, Suite 600, Nashville, TN 37203, United States. Electronic address: Melissa.Wellons@Vanderbilt.edu.
Vanderbilt University · USUniversity of Minnesota · USCedars-Sinai Medical Center · USKaiser Permanente · USLoma Linda University · USNew York Academy of Medicine · USUniversity of Alabama at Birmingham · US

Funding

REGULATION OF MUCIN GENE EXPRESSION BY ELASTASER01HL065611 · NHLBI · DUKE UNIVERSITY · PI VOYNOW, JUDITH A · 2000 to 2003
$1.1M
Increased Cardiovacular Risk and Early Natural Menopause in a Biracial CohortK23HL087114 · NHLBI · VANDERBILT UNIVERSITY · PI WELLONS, MELISSA FAIR · 2008 to 2012
$744k
Genetics of Bone Mineral Density in Two PopulationsF32AR059469 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI YERGES-ARMSTRONG, LAURA MARIA · 2010 to 2011
$98k
Intramural NIH HHSNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS K23 HL087114NHLBI NIH HHS K23-HL-87114NHLBI NIH HHS L30 HL090235NHLBI NIH HHS R01 HL065611NHLBI NIH HHS R01-HL-065611NIAMS NIH HHS F32 AR059469NIA NIH HHS AG0005
6 · The paper itself

Abstract

objectiveAMH is associated with menopausal timing in several studies. In contrast to prior studies that were restricted to women with regular cycles, our objective was to examine this association in women with either regular or irregular menstrual cycles.

methodsCARDIA is a longitudinal, population-based study that recruited adults ages 18-30 when it began in 1985-1986. AMH was measured in serum stored in 2002-2003. Natural menopause was assessed by survey in 2005-2006 and 2010-2011.

resultsAmong 716 premenopausal women, median [25th, 75th] AMH was 0.77 [0.22-2.02]ng/dL at a median age of 42 [39-45] years. Twenty-nine percent of the women (n=207) reported natural menopause during 9 years of follow up. In fully adjusted discrete-time hazard models, a 0.5 ng/dL AMH decrement was associated with higher risk of menopause (p<0.001). Hazard ratios varied with time since AMH measurement. The HR (95% CI) for menopause was 8.1 (2.5-26.1) within 0-3 years and 2.3 (1.7-3.3) and 1.6 (1.3-2.1) for 3-6 and 6-9 years, respectively. When restricted to women with regular menses, results were similar (e.g., HR=6.1; 95% CI: 1.9-20.0 for 0-3 years).

conclusionAMH is independently associated with natural menopause. AMH appears most useful in identifying women at risk of menopause in the near future (within 3 years of AMH measurement).

Indexed as

AdultAnti-Mullerian HormoneBiomarkersFemaleHumansMenopauseMenstruationMiddle AgedAnti-Mullerian HormoneBiomarkersAnti-mullerian hormoneCARDIAFSHMenopauseOvarian agingOvarian reserve

Identifiers

PMID26139426
PMCPMC4515384
OpenAlexW2114499472

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.