Evidence map›Paper›PMID 26139370›Full record

ReviewNeuron2015

Biochemical Computation for Spine Structural Plasticity.

Jun Nishiyama, Ryohei Yasuda

Abstract readReviewVideo-Audio Media
In one paragraph

Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed.

  1. Article
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  6. Two-factor synaptic consolidation reconciles robustness with pruning and homeostatic scaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. Review
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  17. L-type CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. H-Ras induces exuberantiScience · 2024
    Article
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jun NishiyamaMax Planck Florida Institute for Neuroscience, One Max Planck Way, Jupiter, FL 33458, USA.
Ryohei YasudaMax Planck Florida Institute for Neuroscience, One Max Planck Way, Jupiter, FL 33458, USA. Electronic address: ryohei.yasuda@mpfi.org.

Funding

Mechanisms of Ras Signaling in Single SynapsesR01MH080047 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2007 to 2023
$6.8M
Signaling Mechanisms for AMPA Receptor TraffickingR01MH064748 · NIMH · DUKE UNIVERSITY · PI YASUDA, RYOHEI · 2002 to 2011
$2.3M
Imaging signal transduction in single dendritic spinesR01NS068410 · NINDS · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2009 to 2013
$2.0M
Large Scale Development of Sensors for Imaging Small GTPase Signals in SynapsesR01MH095090 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2011 to 2014
$1.7M
NIMH NIH HHS R01 MH064748NIMH NIH HHS R01 MH080047NIMH NIH HHS R01MH080047NIMH NIH HHS R01 MH095090NINDS NIH HHS R01 NS068410NINDS NIH HHS R01NS068410
6 · The paper itself

Abstract

The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity, learning, and memory. The process is mediated by a complex signaling network consisting of numerous species of molecules. Furthermore, the spatiotemporal dynamics of the biochemical signaling are regulated in a complicated manner because of geometrical restrictions from the unique morphology of the dendritic branches and spines. Recent advances in optical techniques have enabled the exploration of the spatiotemporal aspects of the signal regulations in spines and dendrites and have provided many insights into the principle of the biochemical computation that underlies spine structural plasticity.

Indexed as

DendritesDendritic SpinesHumansLearningLong-Term PotentiationNeuronal PlasticitySignal Transduction

Identifiers

PMID26139370
PMCPMC4722820

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.