Evidence map›Paper›PMID 26139364›Full record

ArticleNeuron2015

Dissecting the Role of Smooth Muscle Cells versus Pericytes in Regulating Cerebral Blood Flow Using In Vivo Optical Imaging.

Jenna Mazzoni, Tyler Cutforth, Dritan Agalliu

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Optical imaging and modulation of neurovascular responses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jenna MazzoniDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Tyler CutforthDepartments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Dritan AgalliuDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: da191@cumc.columbia.edu.

Funding

CNS angiogenesis and blood-brain barrier regulation by the Wnt inhibitor Apcdd1.R01HL116995 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGALLIU, DRITAN · 2013 to 2017
$1.9M
NHLBI NIH HHS 1R01HL116995NHLBI NIH HHS R01 HL116995
6 · The paper itself

Abstract

The brain regulates blood flow to match energy demand to nutrient supply. In this issue of Neuron, using in vivo optical imaging and optogenetics, Hill et al. (2015) report that arteriolar smooth muscle cells are key players in regulating cerebral blood flow in the healthy state and contribute to the "no reflow" phenomenon after ischemic stroke.

Indexed as

Brain IschemiaAnimalsCerebral CortexCerebrovascular CirculationHumansMuscle ContractionMyocytes, Smooth MusclePericytes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.