Evidence map›Paper›PMID 26139223›Full record

ArticleSleep & breathing = Schlaf & Atmung2016

Association of Interleukin-10 gene promoter polymorphisms with obstructive sleep apnea.

Sibel Özdaş, Talih Özdaş, Mustafa Acar, Selim S Erbek, Sabri Köseoğlu, Gökhan Göktürk, Afife Izbirak

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Epigenetics of obstructive sleep apnea syndrome: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sibel ÖzdaşFaculty of Science, Department of Biology, Hacettepe University, Beytepe Campus, 06800, Ankara, Turkey. s_unurlu@yahoo.com.
Talih ÖzdaşOtolaryngology Clinic, Yenimahalle Education and Research Hospital, Ankara, Turkey.
Mustafa AcarYunus Emre Hospital, Otolaryngology Clinic, Eskişehir, Turkey.
Selim S ErbekMedical Faculty, Department of Otolaryngology, Başkent University, Ankara, Turkey.
Sabri KöseoğluAnkara Numune Education and Research Hospital, 2. Otolaryngology Clinic, Ankara, Turkey.
Gökhan GöktürkAnkara Numune Education and Research Hospital, 2. Otolaryngology Clinic, Ankara, Turkey.
Afife IzbirakFaculty of Science, Department of Biology, Hacettepe University, Beytepe Campus, 06800, Ankara, Turkey.
Ankara Numune Eğitim ve Araştırma Hastanesi · TRBaşkent University · TREskişehir City Hospital · TRHacettepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterleukin-10 (IL) is an anti-inflammatory cytokine that regulates normal sleep patterns, and recent studies have reported that it is a potential useful biomarker to identify presence and severity of sleep apnea syndrome (OSAS). Promoter polymorphisms of IL-10 gene have been associated with altered expression levels, which contributes to OSAS.

objectiveThe aim of this study was to determine the prevalence of -1082 G/A, -819 C/T, and -592 C/A promoter polymorphisms of IL-10 gene in individuals with OSAS and controls. SUBJECTS AND

methodsAn open-label study was performed in the Otorhinolaryngology and Sleep Disorders Outpatient Clinics. One hundred four cases with OSAS were included as the study group, and 78 individuals without OSAS were included as the controls. DNAs were extracted from peripheral blood leukocytes, and the sites that encompassed those polymorphisms were identified by DNA sequencing analyses. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software.

resultsThe prevalence of OSAS was higher in males in the study group when compared to controls (P = 0.0003). The IL-10-1082 G/A, -819 C/T, and -592 C/A SNPs, and their minor alleles were associated with a significantly increased risk for OSAS compared to the controls (P ˂ 0.05 for all). Furthermore, ATA haplotype frequency was significantly higher in the study group compared to the control group, but the GCC haplotype frequency was lower (P = 0.0001 and P = 0.0001). As indicated in MDR analysis, combinations of IL-10 gene were associated with OSAS in single-, double-, and triple-locus analyses.

conclusionThe prevalences of the IL-10 gene promoter polymorphisms were different in OSAS patients and the controls in Turkish population. IL-10 gene polymorphisms may lead to altered inflammatory cascade, which might contribute to OSAS. Further studies on larger cohorts are needed to validate our findings.

Indexed as

Cross-Sectional StudiesGene ExpressionGenetic MarkersInterleukin-10Multifactor Dimensionality ReductionPolymorphism, GeneticPolymorphism, Single NucleotidePromoter Regions, GeneticReference ValuesSequence Analysis, DNASleep Apnea, ObstructiveGenetic MarkersInterleukin-10DNA sequencing analysisIL-10 geneMultifactor dimensionality reductionObstructive sleep apnea syndromePathogenesisPolymorphism

Identifiers

PMID26139223
OpenAlexW746969068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.