ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Sympathetic baroreflex gain in normotensive pregnant women.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Muscle sympathetic nerve activity during pregnancy: A systematic review and meta-analysis.Physiological reports · 2023Pooled it
- Cardiac output and peripheral vascular resistance during normotensive and hypertensive pregnancy - a systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2022Pooled it
- Temporal Dynamics of Catestatin Across Gestation: Links to Metabolic and Hemodynamic Adaptation.Life (Basel, Switzerland) · 2026Article
- Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans.Experimental physiology · 2026Article
- Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Associations of physical activity and sedentary time with aortic stiffness and autonomic function in early pregnancy.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Postpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Analysis of Circulating Catestatin in Early Pregnancy: A Preliminary Investigation.Biomedicines · 2024Article
- Commentary on: Increased stiffness of omental arteries from late pregnant women at advanced maternal age.Bioscience reports · 2023Article
- Sympathetic Action Potential Firing and Recruitment Patterns Are Abnormal in Gestational Hypertension.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Differential regulation of sympathetic neural burst frequency and amplitude throughout normal pregnancy: a longitudinal study.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Increased respiratory modulation of cardiovascular control reflects improved blood pressure regulation in pregnancy.Frontiers in physiology · 2023Article
- Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Blunted sympathetic neurovascular transduction is associated to the severity of obstructive sleep apnea.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Sequential analysis of heart rate variability, blood pressure variability and baroreflex sensitivity in healthy pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Sympathetic nervous system activity and reactivity in women with gestational diabetes mellitus.Physiological reports · 2020Article
- Influence of multiparity on sympathetic nerve activity during normal pregnancy.American journal of physiology. Heart and circulatory physiology · 2020Article
- Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.Handbook of clinical neurology · 2020Review
- Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa.The Journal of physiology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting. We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregnant women relative to nonpregnant matched controls. Integrated muscle sympathetic burst incidence and total sympathetic activity (microneurography), blood pressure (Finometer), and R-R interval (ECG) were assessed at rest in 11 pregnant women (33 ± 1 wk gestation, 31 ± 1 yr, prepregnancy BMI: 23.5 ± 0.9 kg/m(2)) and 11 nonpregnant controls (29 ± 1 yr; BMI: 25.2 ± 1.7 kg/m(2)). Pregnant women had elevated baseline sympathetic burst incidence (43 ± 2 vs. 33 ± 2 bursts/100 heart beats, P = 0.01) and total sympathetic activity (1,811 ± 148 vs. 1,140 ± 55 au, P < 0.01) relative to controls. Both mean (88 ± 3 vs. 91 ± 2 mmHg, P = 0.4) and diastolic (DBP) (72 ± 3 vs. 73 ± 2 mmHg, P = 0.7) pressures were similar between pregnant and nonpregnant women, respectively, indicating an upward resetting of the baroreflex set point with pregnancy. Baroreflex gain, calculated as the linear relationship between sympathetic burst incidence and DBP, was reduced in pregnant women relative to controls (-3.7 ± 0.5 vs. -5.4 ± 0.5 bursts·100 heart beats(-1)·mmHg(-1), P = 0.03), as was baroreflex gain calculated with total sympathetic activity (-294 ± 24 vs. -210 ± 24 au·100 heart beats(-1)·mmHg(-1); P = 0.03). Cardiovagal baroreflex gain (sequence method) was not different between nonpregnant controls and pregnant women (49 ± 8 vs. 36 ± 8 ms/mmHg; P = 0.2). However, sympathetic (burst incidence) and cardiovagal gains were negatively correlated in pregnant women (R = -0.7; P = 0.02). Together, these data indicate that the influence of the sympathetic nervous system over arterial blood pressure is reduced in normotensive pregnancy, in terms of both long-term and beat-to-beat regulation of arterial pressure, likely through a baroreceptor-dependent mechanism.
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