ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Cerebral blood velocity regulation during progressive blood loss compared with lower body negative pressure in humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Meal Timing on Neurovascular Control in Adults
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Who cites it
19 citing papers in PubMed.
- On-feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation.Experimental physiology · 2026Trial
- Positive pressure ventilation improves oxygen saturation at altitude during recreational aviation: A pilot study.Physiological reports · 2025Trial
- The Benefits of Oral Rehydration on Orthostatic Intolerance in Children with Postural Tachycardia Syndrome.The Journal of pediatrics · 2019Trial
- Early detection of hypovolemia by venous pulse wave velocity and vena cava ultrasound imaging.European journal of applied physiology · 2026Article
- Static autoregulation in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study.Physiological reports · 2024Article
- Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans.European journal of applied physiology · 2024Article
- The effect of oscillatory hemodynamics on the cardiovascular responses to simulated hemorrhage during isocapnia.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Acute beetroot juice consumption does not alter cerebral autoregulation or cardiovagal baroreflex sensitivity during lower-body negative pressure in healthy adults.Frontiers in human neuroscience · 2023Article
- The reciprocal relationship between cardiac baroreceptor sensitivity and cerebral autoregulation during simulated hemorrhage in humans.Autonomic neuroscience : basic & clinical · 2022Review
- A comparison of protocols for simulating hemorrhage in humans: step versus ramp lower body negative pressure.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Preliminary Evidence of Orthostatic Intolerance and Altered Cerebral Vascular Control Following Sport-Related Concussion.Frontiers in neurology · 2021Article
- Article
- Responses of cerebral blood velocity and tissue oxygenation to low-frequency oscillations during simulated haemorrhagic stress in humans.Experimental physiology · 2019Article
- Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI.NeuroImage · 2019Article
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Detecting central hypovolemia in simulated hypovolemic shock by automated feature extraction with principal component analysis.Physiological reports · 2018Article
- Effect of acute hypoxemia on cerebral blood flow velocity control during lower body negative pressure.Physiological reports · 2018Article
- Inferior Vena Cava Diameter is an Early Marker of Central Hypovolemia during Simulated Blood Loss.Prehospital emergency careArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Lower body negative pressure (LBNP) is often used to simulate blood loss in humans. It is unknown if cerebral blood flow responses to actual blood loss are analogous to simulated blood loss during LBNP. Nine healthy men were studied at baseline, during three levels of LBNP (5 min at -15, -30, and -45 mmHg), and during three levels of blood loss (333, 667, and 1,000 ml). LBNP and blood loss conditions were randomized. Intra-arterial mean arterial pressure (MAP) during LBNP was similar to that during blood loss (P ≥ 0.42). Central venous pressure (2.8 ± 0.7 vs. 4.0 ± 0.8, 1.2 ± 0.6 vs. 3.5 ± 0.8, and 0.2 ± 0.9 vs. 2.1 ± 0.9 mmHg for levels 1, 2, and 3, respectively, P ≤ 0.003) and stroke volume (71 ± 4 vs. 80 ± 3, 60 ± 3 vs. 74 ± 3, and 51 ± 2 vs. 68 ± 4 ml for levels 1, 2, and 3, respectively, P ≤ 0.002) were lower during LBNP than blood loss. Despite differences in central venous pressure, middle cerebral artery velocity (MCAv) and cerebrovascular conductance were similar between LBNP and blood loss at each level (MCAv at level 3: 62 ± 6 vs. 66 ± 5 cm/s, P = 0.37; cerebrovascular conductance at level 3: 0.72 ± 0.05 vs. 0.73 ± 0.05 cm·s(-1)·mmHg(-1), P = 0.53). While the slope of the MAP-MCAv relationship was slightly different between LBNP and blood loss (0.41 ± 0.03 and 0.66 ± 0.04 cm·s(-1)·mmHg(-1), respectively, P = 0.05), time domain gain between MAP and MCAv at maximal LBNP/blood loss (P = 0.23) and low-frequency MAP-mean MCAv transfer function coherence, gain, and phase were similar (P ≥ 0.10). Our results suggest that cerebral hemodynamic responses to LBNP to -45 mmHg and blood loss up to 1,000 ml follow a similar trajectory, and the arterial pressure-cerebral blood velocity relationship is not altered from baseline under these conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.