Evidence map›Paper›PMID 26139153›Full record

Trial reportPublic health nutrition2016

Characterisation of anaemia and associated factors among infants and pre-schoolers from rural India.

Krishnapillai Madhavan Nair, Sylvia Fernandez-Rao, Balakrishna Nagalla, Radhakrishna Vijaya Kankipati, Ravinder Punjal, Little Flower Augustine, Kristen M Hurley, Nicholas Tilton, Kimberly B Harding, Greg Reinhart and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Public health nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  11. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Krishnapillai Madhavan Nair1Division of Micronutrient Research,National Institute of Nutrition,Indian Council of Medical Research,Jamai-Osmania PO, Tarnaka,Hyderabad - 500 007,Telangana,India.
Sylvia Fernandez-Rao2Behavioural Sciences,National Institute of Nutrition,Indian Council of Medical Research,Hyderabad,Telangana,India.
Balakrishna Nagalla3Biostatistics,National Institute of Nutrition,Indian Council of Medical Research,Hyderabad,Telangana,India.
Radhakrishna Vijaya Kankipati4Clinical Studies,National Institute of Nutrition,Indian Council of Medical Research,Hyderabad,Telangana,India.
Ravinder Punjal1Division of Micronutrient Research,National Institute of Nutrition,Indian Council of Medical Research,Jamai-Osmania PO, Tarnaka,Hyderabad - 500 007,Telangana,India.
Little Flower Augustine1Division of Micronutrient Research,National Institute of Nutrition,Indian Council of Medical Research,Jamai-Osmania PO, Tarnaka,Hyderabad - 500 007,Telangana,India.
Kristen M Hurley5Department of International Health,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
Nicholas Tilton6Department of Pediatrics,University of Maryland School of Medicine,Baltimore,MD,USA.
Kimberly B Harding7Micronutrient Initiative,Ottawa,Ontario,Canada.
Greg Reinhart8The Mathile Institute for the Advancement of Human Nutrition,Dayton,OH,USA.
Maureen M Black6Department of Pediatrics,University of Maryland School of Medicine,Baltimore,MD,USA.
Indian Council of Medical Research · INNational Institute of Nutrition · INUniversity of Maryland, Baltimore · USJohns Hopkins University · USMathile Institute For The Advancement of Human Nutrition · USNutrition International · CA

Funding

ZINC AND IRON SUPPLEMENTATION: IMPACT ON DEVELOPMENTR01HD037430 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLACK, MAUREEN M. · 1999 to 2002
$1.0M
6 · The paper itself

Abstract

objectiveIn India, national databases indicate anaemia prevalence of 80 % among 6-35-month-old children and 58 % among 36-59-month-old children. The present study aimed to characterise anaemia and the associated factors among infants and pre-schoolers living in rural India.

designMultivariate logistic regression analysis of data collected prior to an intervention trial. Fe-deficiency with anaemia (IDA), Fe deficiency with no anaemia (IDNA) and anaemia without Fe deficiency were defined. Serum ferritin, soluble transferrin receptor (sTfR) and sTfR/log ferritin index were used to indicate Fe status.

settingTwenty-six villages of Nalgonda district, Telangana, India. Data were collected in community sites. Participants Four hundred and seventy-six infants (aged 6-12 months), 316 pre-schoolers (aged 29-56 months) and their mothers.

resultsPrevalence of anaemia among infants and pre-schoolers was 66·4 and 47·8 %, prevalence of IDA was 52·2 and 42·1 %, prevalence of IDNA was 22·2 and 29·8 %, prevalence of anaemia without Fe deficiency was 14·2 and 5·7 %. Among infants, anaemia was positively associated with maternal anaemia (OR=3·31; 95 % CI 2·10, 5·23; P<0·001), and sTfR/log ferritin index (OR=2·21; 95 % CI 1·39, 3·54; P=0·001). Among pre-schoolers, anaemia was positively associated with maternal anaemia (OR=3·77; 95 % CI 1·94, 7·30; P<0·001), sTfR/log ferritin index (OR=5·29; 95 % CI 2·67, 10·50; P<0·001), high C-reactive protein (OR=4·39; 95 % CI 1·91, 10·06, P<0·001) and young age (29-35 months: OR=1·92; 05 % CI 1·18, 3·13, P=0·009).

conclusionsAnaemia prevalence continues to be high among infants and pre-schoolers in rural India. Based on sTfR/ferritin index, Fe deficiency is a major factor associated with anaemia. Anaemia is also associated with inflammation among pre-schoolers and with maternal anaemia among infants and pre-schoolers, illustrating the importance of understanding the aetiology of anaemia in designing effective control strategies.

Indexed as

Iron DeficienciesRural PopulationAnemiaAnemia, Iron-DeficiencyBody Mass IndexBody WeightChild, PreschoolC-Reactive ProteinFamily CharacteristicsFemaleFerritinsFolic AcidFood SupplyHumansIndiaInfantC-Reactive ProteinFerritinsFolic AcidIronMicronutrientsReceptors, TransferrinVitamin B 12AnaemiaIndiaInfantsPre-schoolersRisk factorssTfR/log ferritin index

Identifiers

PMID26139153
PMCPMC10271129
OpenAlexW1689299126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.