Trial reportPsychopharmacology2015
Beta receptor-mediated modulation of the oddball P3 but not error-related ERP components in humans.
Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Transcutaneous vagus nerve stimulation (tVNS) enhances conflict-triggered adjustment of cognitive control.Cognitive, affective & behavioral neuroscience · 2018Trial
- The Reward Positivity Tracks Positive Reward Prediction Errors From Feedback to Cues During Reinforcement Learning.Psychophysiology · 2026Article
- Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event related potential.Frontiers in neuroscience · 2023Article
- Effect of the Trigeminal Nerve Stimulation on Auditory Event-Related Potentials.Cerebral cortex communications · 2021Article
- Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials.Psychopharmacology · 2020Article
- Reduced Frontal Nogo-N2 With Uncompromised Response Inhibition During Transcutaneous Vagus Nerve Stimulation-More Efficient Cognitive Control?Frontiers in human neuroscience · 2020Article
- Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment?Frontiers in psychiatry · 2020Review
- Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level: A Pilot Study.Frontiers in human neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manipulations have so far been limited to agents that affect α2-receptor signaling.
objectivesThe present study investigated whether β-adrenergic receptors are involved in the generation of the P3 and the error positivity (Pe), a component of the event-related potential that is elicited by errors and that bears many similarities to the P3.
methodsWe used a double-blind, placebo-controlled, crossover design in which we examined in human participants (N = 16) the effect of a single dose of propranolol (80 mg) on the amplitudes of the P3 observed in visual and auditory oddball tasks and the Pe observed in a flanker task.
resultsWe found that P3s to auditory stimuli were increased in amplitude following treatment with propranolol. Propranolol also modulated the P3 to visual stimuli, but in a direction dependent on participants' level of trait anxiety: In participants with lower trait anxiety, propranolol resulted in a (non-significant) decrease in P3 amplitudes; in participants with higher trait anxiety, propranolol significantly enhanced P3 amplitude. Propranolol did not modulate the amplitude of the Pe or behavioral measures of conflict/error-related performance adjustments.
conclusionsThese results provide the first evidence for involvement of β-adrenergic receptors in P3 generation. We speculate that propranolol affected the P3 through actions at β2-receptors in the locus coeruleus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.