ArticleHuman brain mapping2015
The influence of mild carbon dioxide on brain functional homotopy using resting-state fMRI.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chronic obstructive pulmonary disease as a risk factor for cognitive impairment: a systematic review and meta-analysis.BMJ open respiratory research · 2024Pooled it
- Systematic Review: Anaesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part A: Effects of Changes in Physiological Parameters.Frontiers in neuroscience · 2020Pooled it
- Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers.BMC psychiatry · 2025Article
- Brain functional alterations in early stage of coal workers' pneumoconiosis with alcoholism: insights from a resting-state fMRI investigation.Frontiers in neuroscience · 2025Article
- Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Changes in Functional Connectivity Between Default Mode Network and Attention Network in Response to Changes in Aerobic Exercise Intensity.Psychiatry investigation · 2023Article
- Separating vascular and neuronal effects of age on fMRI BOLD signals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Interhemispheric Functional Connectivity Alterations in Diabetic Optic Neuropathy: A Resting-State Functional Magnetic Resonance Imaging Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Estimation of brain functional connectivity from hypercapnia BOLD MRI data: Validation in a lifespan cohort of 170 subjects.NeuroImage · 2019Article
- Severe asymptomatic carotid stenosis is associated with robust reductions in homotopic functional connectivity.NeuroImage. Clinical · 2019Article
- Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study.Neuropsychiatric disease and treatment · 2018Article
- Transient immediate postoperative homotopic functional disconnectivity in low-grade glioma patients.NeuroImage. Clinical · 2018Article
- Concussion/mild traumatic brain injury-related chronic pain in males and females: A diagnostic modelling study.Medicine · 2017Article
- Breath-holding during the Calibration Scan Improves the Reproducibility of Parallel Transmission at 7T for Human Brain.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2017Article
- Global Functional Connectivity Differences between Sleep-Like States in Urethane Anesthetized Rats Measured by fMRI.PloS one · 2016Article
- Alteration of spontaneous brain activity in COPD patients.International journal of chronic obstructive pulmonary disease · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Homotopy reflects the intrinsic functional architecture of the brain through synchronized spontaneous activity between corresponding bilateral regions, measured as voxel mirrored homotopic connectivity (VMHC). Hypercapnia is known to have clear impact on brain hemodynamics through vasodilation, but have unclear effect on neuronal activity. This study investigates the effect of hypercapnia on brain homotopy, achieved by breathing 5% carbon dioxide (CO2 ) gas mixture. A total of 14 healthy volunteers completed three resting state functional MRI (RS-fMRI) scans, the first and third under normocapnia and the second under hypercapnia. VMHC measures were calculated as the correlation between the BOLD signal of each voxel and its counterpart in the opposite hemisphere. Group analysis was performed between the hypercapnic and normocapnic VMHC maps. VMHC showed a diffused decrease in response to hypercapnia. Significant regional decreases in VMHC were observed in all anatomical lobes, except for the occipital lobe, in the following functional hierarchical subdivisions: the primary sensory-motor, unimodal, heteromodal, paralimbic, as well as in the following functional networks: ventral attention, somatomotor, default frontoparietal, and dorsal attention. Our observation that brain homotopy in RS-fMRI is affected by arterial CO2 levels suggests that caution should be used when comparing RS-fMRI data between healthy controls and patients with pulmonary diseases and unusual respiratory patterns such as sleep apnea or chronic obstructive pulmonary disease.
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