Trial reportBMC psychiatry2015
Randomized controlled trial of computer-based treatment of social cognition in schizophrenia: the TRuSST trial protocol.
Trial report in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRuSST: Treatment of Social Cognition in Schizophrenia Trial
An Evaluation of a Psychoeducation Program for Emotion Identification and Expression in Individuals Diagnosed With Schizophrenia
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021Pooled it
- Social cognition training improves recognition of individual emotions in schizophrenia disorder.Psychiatry research · 2025Trial
- Trajectories and predictors of response to social cognition training in people with schizophrenia: A proof-of-concept machine learning study.Schizophrenia research · 2024Trial
- Online Social Cognition Training in Schizophrenia: A Double-Blind, Randomized, Controlled Multi-Site Clinical Trial.Schizophrenia bulletin · 2021Trial
- Improving emotion recognition in schizophrenia with "VOICES": An on-line prosodic self-training.PloS one · 2019Trial
- Wide Range Achievement Test word reading subtest score as an indicator of premorbid intellectual disability in serious mental illness.Schizophrenia research. Cognition · 2025Article
- Active Video Games to Improve Behavioral Intentions and Cognitive Function in Patients With Schizophrenia: Randomized Controlled Trial.JMIR serious games · 2025Article
- Cognitive Remediation in Psychiatric Disorders: State of the Evidence, Future Perspectives, and Some Bold Ideas.Brain sciences · 2022Review
- Social cognition training improves recognition of distinct facial emotions and decreases misattribution errors in healthy individuals.Frontiers in psychiatry · 2022Article
- Voices 2: Improving Prosodic Recognition in Schizophrenia With an Online Rehabilitation Program.Frontiers in psychology · 2021Article
- Change in Objective Measure of Empathic Accuracy Following Social Cognitive Training.Frontiers in psychiatry · 2019Article
- e-Motional Training®: Pilot study on a novel online training program on social cognition for patients with schizophrenia.Schizophrenia research. Cognition · 2016Article
- Taking an RDoC lens to the study of panic disorder: A commentary on Hamm et al. and other thoughts on RDoC.Psychophysiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSchizophrenia is a severe and chronic medical condition, characterized by positive and negative symptoms, as well as pervasive social cognitive deficits. Despite the functional significance of the social cognition deficits affecting many aspects of daily living, such as social relationships, occupational status, and independent living, there is still no effective treatment option for these deficits, which is applied as standard of care. To address this need, we developed a novel, internet-based training program that targets social cognition deficits in schizophrenia (SocialVille). Preliminary studies demonstrate the feasibility and initial efficacy of Socialville in schizophrenia patients (Nahum et al., 2014). The purpose of the current trial (referred to as the TReatment of Social cognition in Schizophrenia Trial or TRuSST) is to compare SocialVille to an active control training condition, include a larger sample of patients, and assess both social cognitive functioning, and functional outcomes. METHODS/
designWe will employ a multi-site, longitudinal, blinded, randomized controlled trial (RCT) design with a target sample of 128 patients with schizophrenia. Patients will perform, at their home or in clinic, 40 sessions of either the SocialVille training program or an active control computer game condition. Each session will last for 40-45 minutes/day, performed 3-5 days a week, over 10-12 weeks, totaling to 30 hours of training. Patients will be assessed on a battery of social cognitive, social functioning and functional outcomes immediately before training, mid-way through training (after 20 training sessions) and at the completion of the 40 training sessions. DISCUSSION: The strengths of this protocol are that it tests an innovative, internet-based treatment that targets fundamental social cognitive deficits in schizophrenia, employs a highly sensitive and extensive battery of functional outcome measures, and incorporates a large sample size in an RCT design.
trial registrationClinicalTrials.gov NCT02246426 Registered 16 September 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.