Evidence map›Paper›PMID 26138702›Full record

ArticleEndocrine connections2015

Fructose content of low calorie diets: effect on cardiometabolic risk factors in obese women with polycystic ovarian syndrome: a randomized controlled trial.

Line K Johnson, Kirsten B Holven, Njord Nordstrand, Jan R Mellembakken, Tom Tanbo, Jøran Hjelmesæth

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine connections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00779571 (Treatment of PCOS), which is not on this map. Cited by 13 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 7 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00779571 nacompletednot on this map

Treatment of PCOS (Polycystic Ovary Syndrome)in Morbidly Obese Women - A Randomized Controlled Prospective Dietary Intervention Study

TypeinterventionalSponsorThe Hospital of VestfoldRan2008 to 2012Enrolled61ConditionsPolycystic Ovary Syndrome, Morbid ObesityArmsCrispbread
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 7 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Lifestyle changes in women with polycystic ovary syndrome.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Review
  10. Review
  11. Review
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Line K JohnsonMorbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway line.kristin.johnson@siv.no.
Kirsten B HolvenMorbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway Morbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway.
Njord NordstrandMorbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway.
Jan R MellembakkenMorbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway.
Tom TanboMorbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway Morbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway.
Jøran HjelmesæthMorbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway Morbid Obesity CentreVestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, NorwayDepartment of NutritionInstitute of Basic Medical Sciences, University of Oslo, PO Box 1046 Blindern, 0317 Oslo, NorwayNorwegian National Advisory Unit on Familial HypercholesterolemiaDepartment of Endocrinology, Morbid Obesity and Preventive MedicineDepartment of GynecologyOslo University Hospital, Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, NorwayInstitute of Clinical MedicineDepartment of EndocrinologyMorbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, PO Box 1171 Blindern, 0318 Oslo, Norway.
Oslo University Hospital · NOSykehuset i Vestfold · NODiabetes Australia · AUUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to examine whether a whole-grain crispbread (CB) low-fructose, low-calorie diet (LCD) might be superior to a traditional LCD based on fructose-rich liquid meal replacements (LMRs) with respect to improvement of various cardiometabolic risk factors and reproductive hormones. Parallel-group randomised controlled clinical trial. Morbidly obese women with polycystic ovarian syndrome (PCOS) were randomised to either an 8-week CB-LCD or LMR-LCD (900-1100 kcal/day, fructose 17 g/day or 85 g/day). A total of 51 women completed the study. Body weight, fat mass and waist circumference reduced by mean (s.d.) 10.0 (4.8) kg, 7.4 (4.2) kg and 8.5 (4.4) cm, with no significant differences between groups. Total-cholesterol, HDL-cholesterol and Apo-A1 were significantly reduced within both groups (all P values <0.01), with no significant between-group differences. The triacylglycerol and LDL-cholesterol levels were reduced within the LMR group only, with no significant between-group differences. Blood pressure and most measures of glucose metabolism improved significantly in both diet groups, with no significant between-group difference. Uric acid levels rose by 17.7 (46.4) and 30.6 (71.5) μmol/l in the CB and LMR group, respectively, with no significant difference between groups. Gastrointestinal discomfort was significantly and equally reduced in both intervention groups. Free testosterone index was reduced in both groups, with no significant difference between groups. Morbidly obese women with PCOS who underwent either an 8-week low or high-fructose LCD-diet had similar changes in various cardiometabolic risk factors and reproductive hormones. Registration at ClinicalTrials.gov: NCT00779571.

Indexed as

cardiometabolic risk-factorsfructoselow calorie dietsobesityPCOSweight loss

Identifiers

PMID26138702
PMCPMC4488759
OpenAlexW2292420491

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.