ArticleHealth and quality of life outcomes2015
Health related quality of life in adolescents with chronic fatigue syndrome: a cross-sectional study.
Article in Health and quality of life outcomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Which needs do children, adolescents, and young adults with ME/CFS and their parents express and feel? - Qualitative study in Germany.BMC public health · 2026Article
- Validation of the Wood Mental Fatigue Inventory in adolescents with myalgic encephalomyelitis/chronic fatigue syndrome.Brain, behavior, & immunity - health · 2026Article
- Symptom burden among long-term survivors of young adult cancer: a report from the Project Milestones cohort.Journal of cancer survivorship : research and practice · 2026Article
- The influence of adolescents essential and non-essential use of technology and Internet addiction on their physical and mental fatigues.Scientific reports · 2024Article
- Effect of elevated depressive symptoms during adolescence on health-related quality of life in young adulthood-a six-year cohort study with repeated exposure measurements.Frontiers in pediatrics · 2024Article
- Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan.Journal of translational medicine · 2023Article
- Case report: Recurrent cervical spinal stenosis masquerading as myalgic encephalomyelitis/chronic fatigue syndrome with orthostatic intolerance.Frontiers in neurology · 2023Article
- One-year follow-up of young people with ME/CFS following infectious mononucleosis by Epstein-Barr virus.Frontiers in pediatrics · 2023Article
- Pediatric Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Overlaps and Opportunities.The Pediatric infectious disease journal · 2022Article
- Parent-child discrepancies in health-related quality of life of children and adolescents with myalgic encephalomyelitis/chronic fatigue syndrome.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Healthcare (Basel, Switzerland) · 2021Review
- Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.Journal of clinical medicine · 2021Article
- Exploring anhedonia in adolescents with Chronic Fatigue Syndrome (CFS): A mixed-methods study.Clinical child psychology and psychiatry · 2021Article
- Health-related quality of life in Norwegian adolescents living with chronic fatigue syndrome.Health and quality of life outcomes · 2020Article
- Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function.PloS one · 2020Article
- Developing and pretesting a new patient reported outcome measure for paediatric Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME): cognitive interviews with children.Journal of patient-reported outcomes · 2019Article
- The psychosocial needs and quality of life of family caregivers of patients with organ transplant.Journal of research in nursing : JRN · 2019Article
- Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study.Journal of translational medicine · 2019Article
- Impaired Health-Related Quality of Life in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Impact of Core Symptoms.Frontiers in pediatrics · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study health related quality of life (HRQOL) and depressive symptoms in adolescents with chronic fatigue syndrome (CFS) and to investigate in which domains their HRQOL and depressive symptoms differ from those of healthy adolescents. BACKGROUND AND
objectiveSeveral symptoms such as disabling fatigue, pain and depressive symptoms affect different life domains of adolescents with CFS. Compared to adolescents with other chronic diseases, young people with CFS are reported to be severely impaired, both physiologically and mentally. Despite this, few have investigated the HRQOL in this group.
methodThis is a cross-sectional study on HRQOL including 120 adolescents with CFS and 39 healthy controls (HC), between 12 and 18 years. The Pediatric Quality of Life Inventory™, 4.0 (PedsQL) was used to assess HRQOL. The Mood and Feelings Questionnaire assessed depressive symptoms. Data were collected between March 2010 and October 2012 as part of the NorCAPITAL project (Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial). Linear and logistic regression models were used in analysis, and all tests were two-sided.
resultsAdolescents with CFS reported significantly lower overall HRQOL compared to HCs. When controlling for gender differences, CFS patients scored 44 points lower overall HRQOL on a scale from 0-100 compared to HCs. The domains with the largest differences were interference with physical health (B = -59, 95 % CI -54 to -65) and school functioning (B = -52, 95 % CI -45 to -58). Both depressive symptoms and being a patient were independently associated with lower levels of HRQOL
conclusionThe difference in HRQOL between CFS patients and healthy adolescents was even larger than we expected. The large sample of adolescents with CFS in our study confirms previous findings from smaller studies, and emphasizes that CFS is a seriously disabling condition that has a strong impact on their HRQOL. Even though depressive symptoms were found in the group of patients, they could not statistically explain the poor HRQOL.
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