Evidence map›Paper›PMID 26138652›Full record

ArticleDigestive diseases and sciences2015

Nod2-Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats.

Guoguang Ma, Bin Shi, Jingquan Liu, Hongze Zhang, Zijun YinTao, Xiaoli Lou, Dongyu Liang, Yanqiang Hou, Shengxia Wan, Wanhua Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Guoguang MaDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China.
Bin ShiDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China. 18918288036@163.com.
Jingquan LiuDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China.
Hongze ZhangDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China.
Zijun YinTaoDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China.
Xiaoli LouDepartment of Central Laboratory, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, Shanghai, 201600, China.
Dongyu LiangDepartment of Central Laboratory, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, Shanghai, 201600, China.
Yanqiang HouDepartment of Central Laboratory, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, Shanghai, 201600, China.
Shengxia WanDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China.
Wanhua YangDepartment of General Intensive Care Unit, Songjiang Hospital Affiliated to First People's Hospital, Shanghai Jiao Tong University, No. 746, Zhongshan Road, Shanghai, 201600, China.
Shanghai Jiao Tong University · CNSongjiang District Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPepT1 can transport bacterial oligopeptide products and induce intestinal inflammation. Our aim was to investigate the mechanism of the small intestine injury induced by bacterial oligopeptide product muramyl dipeptide (MDP) which is transported by PepT1.

methodsWe perfused the jejunum with a solution with or without MDP, or with a solution of MDP + Gly-Gly and explored the degree of inflammation to determine the role of PepT1-Nod2 signaling pathway in small intestine mucosa.

resultsMDP perfusion induced inflammatory cell accumulation and intestinal damage, accompanied by an increase in mucosal Nod2 and Rip2 transcript expression. NFκB activity and inflammatory cytokine expression, including serum levels of TNF-α, IL-1β, and IL-6, increased in the MDP group compared to the controls; these effects were reversed by perfusion of the nutritional dipeptide Gly-Gly.

conclusionMDP can be transported through PepT1, causing inflammatory damage in the rat small intestine. Nod2-Rip2-NFκB signaling involved in the small intestinal inflammatory injury caused by MDP which is transported through PepT1.

Indexed as

Acetylmuramyl-Alanyl-IsoglutamineAnimalsCytokinesEnteritisGlycylglycineInflammation MediatorsIntestinal MucosaJejunumMaleNF-kappa BNod2 Signaling Adaptor ProteinPeptide Transporter 1Rats, Sprague-DawleyReceptor-Interacting Protein Serine-Threonine Kinase 2Signal TransductionSymportersAcetylmuramyl-Alanyl-IsoglutamineCytokinesGlycylglycineInflammation MediatorsNF-kappa BNOD2 protein, ratNod2 Signaling Adaptor ProteinPeptide Transporter 1Receptor-Interacting Protein Serine-Threonine Kinase 2Slc15a1 protein, ratSymportersMuramyl dipeptide (MDP)Nod signaling adaptor proteinPepT1 proteinSmall intestine injury

Identifiers

PMID26138652
OpenAlexW834503791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.