SynthesisBMC ophthalmology2015
Choroidal thickness and high myopia: a cross-sectional study and meta-analysis.
Synthesis in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Choroidal Thickness and Its Association With Age, Axial Length, and Refractive Error in Chinese Adults.Investigative ophthalmology & visual science · 2022Pooled it
- Refractive Error and Eye Health: An Umbrella Review of Meta-Analyses.Frontiers in medicine · 2021Pooled it
- Associations Between Choroidal Structural Parameters and Cone Photoreceptors in Young High Myopia.Translational vision science & technology · 2026Article
- Ocular Component Growth From the Cornea to the Sclera in Non-Human Primate Emmetropization.Investigative ophthalmology & visual science · 2026Article
- Influence of body position and time of day on ocular rhythms.Scientific reports · 2025Article
- Analysis of the correlations between changes in posterior segment and anterior chamber segment after implantable collamer lens implantation in highly myopic patients.BMC ophthalmology · 2025Observational
- The association between subfoveal choroidal thickness and refractive error in Taiwanese children: A cross-sectional study.PloS one · 2025Article
- Distribution and associated factors of choroidal thickness in highly myopic eyes-a real-world study based on a Chinese population.Eye (London, England) · 2025Article
- A novel multi-scale and fine-grained network for large choroidal vessels segmentation in OCT.Frontiers in cell and developmental biology · 2025Article
- Omega-3 Polyunsaturated Fatty Acids as a Protective Factor for Myopia.American journal of ophthalmology · 2024Article
- Lacquer cracks in pathological myopia: a clinical review.Eye (London, England) · 2024Review
- Comparison of manual and artificial intelligence-automated choroidal thickness segmentation of optical coherence tomography imaging in myopic adults.Eye and vision (London, England) · 2024Article
- Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression.BMJ open ophthalmology · 2024Article
- Impact of Brightness on Choroidal Vascularity Index.Journal of clinical medicine · 2024Article
- Assessment of macular choroidal and retinal thickness: a cohort study in Tibetan healthy children.Scientific reports · 2024Article
- The Clinical Role of the Choroidal Assessment in High Myopia: Characteristics and Association With Neovascular and Atrophic Complications.Investigative ophthalmology & visual science · 2023Article
- Characteristics and treatment response of polypoidal choroidal vasculopathy in highly myopic eyes.Eye (London, England) · 2023Article
- A Deep Learning-Based Fully Automated Program for Choroidal Structure Analysis Within the Region of Interest in Myopic Children.Translational vision science & technology · 2023Article
- Effects of inflammation on myopia: evidence and potential mechanisms.Frontiers in immunology · 2023Review
- SubFoveal Choroidal Imaging in High Myopic Nepalese Cohort.Journal of ophthalmology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to examine the choroidal thickness of patients with high myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare them with healthy subjects.
methodsWe first conducted a cross-sectional study and then performed a meta-analysis to address this issue further. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the macular choroidal thickness of high myopic eyes and normal control eyes were measured and compared at each location. Univariate and multivariate linear regression analyses were performed to assess the association between choroidal thickness and clinical factors such as axial length (AL), spherical equivalent (SE), and central corneal thickness. In the high myopic eyes, subgroup analysis of macular choroidal thickness was performed in eyes with or without lacquer cracks and choroidal neovascularization (CNV). The meta-analyses were conducted using the Stata software package.
resultsThe high myopic eyes had a thinner choroid than the control eyes at all macular locations (all P < 0.001). Multivariable linear regression analysis showed that the subfoveal choroidal thickness (SFCT) was not significantly thinner in association with the diagnosis. Subgroup analysis showed that the high myopia with CNV and with lacquer cracks had a significantly thinner choroid than without CNV or lacquer crack eyes. The result of our cross-sectional study is consistent with the results of the further meta-analysis with the pooled weighted mean difference (WMD) of -116.30 μm (95 % CI: -145.68, -86.92) for SFCT.
conclusionsThe present study, along with the comprehensive meta-analysis, indicated that in the Chinese population, the choroidal thickness in high myopic eyes was thinner than that of normal control eyes, even across different subgroups. This might be secondary to the longer AL but it is not an independent factor. The presence of CNV and of lacquer cracks is associated strongly with eyes with thinner macular choroids.
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