ArticleEuropean journal of nutrition2016
Folic acid supplementation, dietary folate intake and risk of preterm birth in China.
Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Folic Acid and Risk of Preterm Birth: A Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis.Archives of gynecology and obstetrics · 2018Pooled it
- Maternal calcium, phosphorus, and supplement intake before and during pregnancy and their association with preterm birth risk: based on a large cohort study.Journal of health, population, and nutrition · 2026Article
- Correlation between folic acid and hemoglobin in pregnant women: cross-sectional study from 2017 to 2019.Revista brasileira de enfermagem · 2026Article
- Maternal Folic Acid Supplement Use, Folate Intake, and Preterm Birth Among Infants With Spina Bifida.Birth defects research · 2025Article
- Maternal iron and zinc and preterm labor risk: A nested case-control study based on the Lanzhou Birth Cohort Study (BBCS) in China.Asia Pacific journal of clinical nutrition · 2025Article
- Article
- Impact of maternal iron and zinc intake on low birth weight risk: a nested case-control study.PeerJ · 2025Article
- Folate deficiency in pregnancy and the risk of preterm birth: A nested case-control study.Journal of global health · 2024Article
- The association of preconceptional folic acid supplementation with gestational age and preterm birth risk in twin pregnancies: a prospective cohort study in China.European journal of nutrition · 2024Article
- Vitamin C Alleviates the Risk of Gestational Diabetes Mellitus Associated With Exposure to Metals.Journal of diabetes research · 2024Article
- Article
- The interaction between no folic acid supplementation during early pregnancy and preeclampsia increased the risk of preterm birth.Saudi medical journal · 2023Article
- Nonlinear Relationship Between Maternal and Cord Blood Vitamin BInternational journal of women's health · 2023Article
- Effects of Benzo[a]pyrene-DNA adducts, dietary vitamins, folate, and carotene intakes on preterm birth: a nested case-control study from the birth cohort in China.Environmental health : a global access science source · 2022Article
- Associations of B Vitamin-Related Dietary Pattern during Pregnancy with Birth Outcomes: A Population-Based Study in Northwest China.Nutrients · 2022Article
- Association between Folic Acid Supplementation and Hypertensive Disorder Complicating Pregnancy in Jiangsu Province: A Cross-Sectional Study.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study.Frontiers in public health · 2022Article
- Association between Iron Supplementation, Dietary Iron Intake and Risk of Moderate Preterm Birth: A Birth Cohort Study in China.Iranian journal of public health · 2021Article
- The association between periconceptional folic acid supplementation and the risk of preterm birth: a population-based retrospective cohort study of 200,000 women in China.European journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
32 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFolic acid supplementation has been suggested to reduce the risk of preterm birth. However, results from previous epidemiologic studies have been inconclusive. We investigated the hypothesis that folic acid supplementation and dietary folate intake during pre- and post-conception reduces the risk of preterm birth.
methodsWe analyzed data from a birth cohort study conducted between 2010 and 2012 in Lanzhou, China, including 10,179 pregnant women with live singleton births.
resultsCompared to non-users, folic acid supplement users with >12-week duration had a reduced risk of preterm birth (OR 0.67, 95 % CI 0.55-0.83) with a significant dose-response relationship (P for trend = 0.01). A similar pattern was observed for spontaneous preterm birth. Stronger associations were seen for ever use of folic acid supplement and very preterm birth (OR 0.50, 95 % CI 0.36-0.69) and spontaneous very preterm birth (OR 0.42, 95 % CI 0.29-0.63). Dietary folate intake during preconception and pregnancy were also associated with reduced risk of preterm birth (OR 0.68, 95 % CI 0.56-0.83, OR 0.57, 95 % CI 0.47-0.70 for the highest quartiles, respectively), particularly for spontaneous very preterm (OR 0.41, 95 % CI 0.24-0.72, OR 0.26, 95 % CI 0.15-0.47 for the highest quartiles, respectively). There were also decreased risks of preterm birth observed per 10-µg increase in dietary folate intake, and similar associations were found after stratification by folic acid supplementation status.
conclusionsOur results suggest that folic acid supplementation and higher dietary folate intake during preconception and pregnancy reduces the risk of preterm birth, and the protective effect varies by preterm subtypes.
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