ArticleBMC research notes2015
Bloodstream bacterial infection among outpatient children with acute febrile illness in north-eastern Tanzania.
Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PLoS neglected tropical diseases · 2022Pooled it
- Prevalence and outcome of bloodstream infections due to third-generation cephalosporin-resistant Enterobacteriaceae in sub-Saharan Africa: a systematic review.The Journal of antimicrobial chemotherapy · 2020Pooled it
- Pediatric empiric antibiotic use and resistance patterns at a single tertiary care hospital in Tanzania.BMC pediatrics · 2026Article
- Geospatial Mapping of Pediatric Febrile Illness in Uganda to Inform Precision Public Health Interventions.Open forum infectious diseases · 2026Article
- Bacterial etiology and antimicrobial resistance in bloodstream infections at the University of Gondar Comprehensive Specialized Hospital: a cross-sectional study.Frontiers in microbiology · 2025Article
- Bacterial isolates, antibiotic susceptibility, and determinants of positive blood culture in children with community-acquired pneumonia in Central Tanzania.The Pan African medical journal · 2025Article
- Antimicrobial resistance in Enterobacterales infections among children in sub-Saharan Africa: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing.Nature communications · 2024Article
- Factors associated with pediatric febrile illnesses in 27 countries of Sub-Saharan Africa.BMC infectious diseases · 2023Article
- Bacteriological Profile and Antimicrobial Susceptibility Patterns of Bloodstream Infection at Kigali University Teaching Hospital.Infection and drug resistance · 2021Article
- Prevalence and Clinical Management of Non-malarial Febrile Illnesses among Outpatients in the Era of Universal Malaria Testing in Malawi.The American journal of tropical medicine and hygiene · 2020Article
- The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Review
- Antimicrobial Resistance of Sterile Site Infections in Sub-Saharan Africa: A Systematic Review.Open forum infectious diseases · 2017Article
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8 authors.
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Abstract
backgroundFever is a common clinical symptom in children attending hospital outpatient clinics in rural Tanzania, yet there is still a paucity of data on the burden of bloodstream bacterial infection among these patients.
methodsThe present study was conducted at Korogwe District Hospital in north-eastern Tanzania. Patients aged between 2 and 59 months with a history of fever or measured axillary temperature ≥37.5°C attending the outpatient clinic were screened for enrolment into the study. Blood culturing was performed using the BACTEC 9050® system. A biochemical analytical profile index and serological tests were used for identification and confirmation of bacterial isolates. In-vitro antimicrobial susceptibility testing was performed using the Kirby-Bauer disc diffusion method. The identification of Plasmodium falciparum malaria was performed by microscopy with Giemsa stained blood films.
resultsA total of 808 blood cultures were collected between January and October 2013. Bacterial growth was observed in 62/808 (7.7%) of the cultured samples. Pathogenic bacteria were identified in 26/808 (3.2%) cultures and the remaining 36/62 (58.1%) were classified as contaminants. Salmonella typhi was the predominant bacterial isolate detected in 17/26 (65.4%) patients of which 16/17 (94.1%) were from patients above 12 months of age. Streptococcus pneumoniae was the second leading bacterial isolate detected in 4/26 (15.4%) patients. A high proportion of S. typhi 11/17 (64.7%) was isolated during the rainy season. S. typhi isolates were susceptible to ciprofloxacin (n = 17/17, 100%) and ceftriaxone (n = 13/17, 76.5%) but resistant to chloramphenicol (n = 15/17, 88.2%). P. falciparum malaria was identified in 69/808 (8.5%) patients, none of whom had bacterial infection.
conclusionBloodstream bacterial infection was not found to be a common cause of fever in outpatient children; and S. typhi was the predominant isolate. This study highlights the need for rational use of antimicrobial prescription in febrile paediatric outpatients presenting at healthcare facilities in rural Tanzania.
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