SynthesisTrials2015
Effect of non-surgical periodontal treatment on glycemic control of patients with diabetes: a meta-analysis of randomized controlled trials.
Synthesis in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 8 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review.Oral diseases · 2025Pooled it
- Effects of Periodontal Therapy on Cardiovascular Risk Biomarkers: A Systematic Review.Oral health & preventive dentistry · 2025Pooled it
- An umbrella review of systematic reviews examining the relationship between type 2 diabetes and periodontitis: Position paper from the Canadian Dental Hygienists Association.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association.Nutrients · 2020Pooled it
- Effects of non-surgical periodontal therapy on systemic inflammation and metabolic markers in patients undergoing haemodialysis and/or peritoneal dialysis: a systematic review and meta-analysis.BMC oral health · 2020Pooled it
- The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review.Clinical oral investigations · 2018Pooled it
- Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis.BMC oral health · 2017Pooled it
- Systematic review and assessment of systematic reviews examining the effect of periodontal treatment on glycemic control in patients with diabetes.Medicina oral, patologia oral y cirugia bucal · 2017Pooled it
- Clinical Outcomes and Oral Health-Related Quality of Life after Periodontal Treatment with Community Health Worker Strategy in Patients with Type 2 Diabetes: A Randomized Controlled Study.International journal of environmental research and public health · 2021Trial
- Dental Intervention on the Quality of Life of Metabolic Syndrome Patients: A Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Nonsurgical Periodontal Therapy for Diabetes Patients with Periodontal Disease.Journal of clinical and experimental dentistry · 2026Review
- The Connection Between the Oral Microbiota and the Kynurenine Pathway: Insights into Oral and Certain Systemic Disorders.Current issues in molecular biology · 2024Review
- Alveolar Bone Loss in Diabetic Patients: A Case-Control Study.European journal of dentistry · 2024Article
- Current scientific evidence for why periodontitis should be included in diabetes management.Frontiers in clinical diabetes and healthcare · 2023Article
- Association between Periodontitis and Diabetes Mellitus in the General Population.Journal of diabetes and metabolic disorders · 2022Article
- State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature.Journal of clinical medicine · 2021Review
- Assessment of Effect of Periodontal and Prosthodontic Therapy on Glycemic Control in Patients with Diabetes.Journal of pharmacy & bioallied sciences · 2021Article
- Baseline HbA1c Level Influences the Effect of Periodontal Therapy on Glycemic Control in People with Type 2 Diabetes and Periodontitis: A Systematic Review on Randomized Controlled Trails.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Massive data analyses show negative impact of type 1 and 2 diabetes on the outcome of periodontal treatment.Clinical oral investigations · 2021Article
- Periodontal Treatment Protocol for Decompensated Diabetes Patients.Frontiers in oral health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aimed at investigating whether non-surgical periodontal treatment can reduce the Haemoglobin A1c (HbA1c) % level in type 2 diabetic patients.
methodsA search of the literature on English publications was performed in Cochrane Central, Medline, ISI Web of Knowledge and EMBASE (until 06 February 2014). An RCT was selected if the subject was type 2 diabetic patients diagnosed with chronic periodontitis, and compared HbA1c% change after non-surgical periodontal treatment alone for at least three months of the study duration. Weighted mean difference for pooled data and large sample size strata were calculated. Heterogeneity and publication bias were explored.
resultsAfter the study selection process, only 9 RCTs were suitable. Compared to the control group, the pooled analysis (n=1082) showed -0.27% (95% CI:-0.46% to -0.07%, p = 0.007) absolute difference in HbA1c % with treatment while studies with sufficient sample size had HbA1c% change of -0.014% (95% CI:-0.18% to 0.16%, p = 0.87). Publication bias was marginally significant with Egger's teat (p=0.045) but not with Begg's test (p=0.72).
conclusionThe moderate reduction in HbA1c after the non-surgical therapy in patients with type 2 diabetes is consistent with previous systematic reviews. However, more large scale and high-quality RCTs are necessitated to confirm these results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.