ArticleEBioMedicine2015
3-D Imaging Reveals Participation of Donor Islet Schwann Cells and Pericytes in Islet Transplantation and Graft Neurovascular Regeneration.
Article in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The neuro-vascular-immune triad: the interactive network in the tumor microenvironment.Cell communication and signaling : CCS · 2026Review
- Schwann Cells in Digestive System Disorders.Cells · 2022Review
- A Novel ex vivo Method for Investigating Vascularization of Transplanted Islets.Journal of vascular research · 2022Article
- Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes.Frontiers in endocrinology · 2021Review
- A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes.Science advances · 2020Article
- Immune regulation of islet homeostasis and adaptation.Journal of molecular cell biology · 2020Review
- Recruited fibroblasts reconstitute the peri-islet membrane: a longitudinal imaging study of human islet grafting and revascularisation.Diabetologia · 2020Article
- Lymphatic vessel remodeling and invasion in pancreatic cancer progression.EBioMedicine · 2019Article
- Targeting pericytes for neurovascular regeneration.Cell communication and signaling : CCS · 2019Review
- The Role of Accessory Cells in Islet Homeostasis.Current diabetes reports · 2018Review
- Optical clearing of the pancreas for visualization of mature β-cells and vessels in mice.Islets · 2018Article
- Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca.International journal of oral science · 2018Article
- The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow.Cell metabolism · 2018Article
- Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology.Diabetologia · 2018Article
- PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3D pancreatic duct lesion histology.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Pancreatic islet blood flow and its measurement.Upsala journal of medical sciences · 2016Review
- 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice.International journal of obesity (2005) · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barriers at the islet exterior and interior borders. The two cell types have shown their plasticity in islet injury, but their roles in transplantation remain unclear. In this research, we applied 3-dimensional neurovascular histology with cell tracing to reveal the participation of Schwann cells and pericytes in mouse islet transplantation. Longitudinal studies of the grafts under the kidney capsule identify that the donor Schwann cells and pericytes re-associate with the engrafted islets at the peri-graft and perivascular domains, respectively, indicating their adaptability in transplantation. Based on the morphological proximity and cellular reactivity, we propose that the new islet microenvironment should include the peri-graft Schwann cell sheath and perivascular pericytes as an integral part of the new tissue.
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