Evidence map›Paper›PMID 26137497›Full record

ReviewJournal of diabetes research2015

Diabetic Retinopathy: Vascular and Inflammatory Disease.

F Semeraro, A Cancarini, R dell'Omo, S Rezzola, M R Romano, C Costagliola

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04378972 (Analysis of Soluble Mediators of Inflammation and Angiogenesis in the Vitreous of Patients With Diabetic Retinopathy Treated With Curcumin/Homotaurine/Vit. D3), which is not on this map. Cited by 226 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 8 pooled it
33.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04378972 completednot on this mapstarted 2019, after this paper: background citation

Analysis of Soluble Mediators of Inflammation and Angiogenesis in the Vitreous of Patients With Diabetic Retinopathy Treated With Curcumin/Homotaurine/Vit. D3

TypeobservationalSponsorUniversity of MoliseRan2019 to 2019Enrolled25ConditionsDiabetic RetinopathyArmscurcumin, homotaurine, vitamin D3, control
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 8 syntheses or guidelines pooled it, 406 citations in OpenAlex.

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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

F SemeraroDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
A CancariniDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
R dell'OmoDepartment of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
S RezzolaDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
M R RomanoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples, Italy.
C CostagliolaDepartment of Medicine and Health Sciences, University of Molise, Campobasso, Italy ; ICRRS Neuromed, Pozzilli, Isernia, Italy.
University of Brescia · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR are not completely characterized. Previous studies indicate that tissue hypoxia and dysregulation of immune responses associated with diabetes mellitus can induce increased expression of numerous vitreous mediators responsible for DR development. Thus, analysis of vitreous humor obtained from diabetic patients has made it possible to identify some of the mediators (cytokines, chemokines, and other factors) responsible for DR pathogenesis. Further studies are needed to better understand the relationship between inflammation and DR. Herein the main vitreous-related factors triggering the occurrence of retinal complication in diabetes are highlighted.

Indexed as

Blood GlucoseCytokinesDiabetic RetinopathyHumansHypoxiaInflammationMitochondriaOxidative StressRetinaRetinal VesselsBlood GlucoseCytokines

Identifiers

PMID26137497
PMCPMC4475523
OpenAlexW1518103124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.