ReviewFrontiers in medicine2015
Epigenetic Mechanisms Leading to Overexpression of HMGA Proteins in Human Pituitary Adenomas.
Review in Frontiers in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- HMGA proteins in the nervous system: role in brain tumorigenesis and neurodegeneration.Cell death discovery · 2026Review
- Lower miR-26a levels in breastmilk affect gene expression in adipose tissue of offspring.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell.Oncogenesis · 2021Article
- HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression.Aging · 2021Article
- GH and IGF System: The Regulatory Role of miRNAs and lncRNAs in Cancer.Frontiers in endocrinology · 2021Review
- Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.Endocrine reviews · 2020Review
- Biomarkers for Liquid Biopsies of Pituitary Neuroendocrine Tumors.Biomedicines · 2020Review
- IncreasedDiagnostics (Basel, Switzerland) · 2020Article
- RPSAP52 lncRNA Inhibits p21Waf1/CIP Expression by Interacting With the RNA Binding Protein HuR.Oncology research · 2020Article
- MiR‑495 suppresses cell proliferation by directly targeting HMGA2 in lung cancer.Molecular medicine reports · 2019Article
- miR-16 regulates proliferation and apoptosis of pituitary adenoma cells by inhibiting HMGA2.Oncology letters · 2019Article
- The Epigenomics of Pituitary Adenoma.Frontiers in endocrinology · 2019Review
- HMGA2 Antisense Long Non-coding RNAs as New Players in the Regulation of HMGA2 Expression and Pancreatic Cancer Promotion.Frontiers in oncology · 2019Article
- Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells.Molecular and cellular biology · 2018Article
- Transcriptional Regulation of Glucose Metabolism: The Emerging Role of the HMGA1 Chromatin Factor.Frontiers in endocrinology · 2018Review
- Autocrine IL-6 mediates pituitary tumor senescence.Oncotarget · 2017Article
- Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation.Oncotarget · 2016Article
- HMGA1-pseudogenes and cancer.Oncotarget · 2016Review
- Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives.Oncotarget · 2016Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the high-mobility group A (HMGA)1 and HMGA2 proteins is a feature of all human pituitary adenoma (PAs) subtypes. However, amplification and/or rearrangement of the HMGA2 have been described in human prolactinomas, but rarely in other pituitary subtypes, and no genomic amplification of HMGA1 was detected in PAs. Here, we summarize the functional role of HMGA proteins in pituitary tumorigenesis and the epigenetic mechanisms contributing to HMGA overexpression in these tumors focusing on recent studies indicating a critical role of non-coding RNAs in modulating HMGA protein levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.