ArticleNeuroImage. Clinical2015
Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Resting-state functional connectivity alterations in dementia with Lewy bodies: a systematic review and activation likelihood estimation meta-analysis.Brain imaging and behavior · 2026Pooled it
- Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease.Clinical epigenetics · 2026Article
- Correlation of Parkinson's disease severity andQuantitative imaging in medicine and surgery · 2025Article
- Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease.Human brain mapping · 2024Article
- Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson's Disease.NPJ Parkinson's disease · 2022Article
- A Novel and Selective Dopamine Transporter Inhibitor,Biomolecules · 2022Article
- Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers.NPJ Parkinson's disease · 2022Article
- Lewy Body Dementias: A Coin with Two Sides?Behavioral sciences (Basel, Switzerland) · 2021Review
- Cognitive Decline in Parkinson's Disease: A Subgroup of Extreme Decliners Revealed by a Data-Driven Analysis of Longitudinal Progression.Frontiers in psychology · 2021Article
- Development of Hippocampal-Prefrontal Cortex Interactions through Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Interactive effects of dopamine transporter genotype and aging on resting-state functional networks.PloS one · 2019Article
- Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults.Neurobiology of aging · 2018Article
- Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?NeuroImage. Clinical · 2018Review
- Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson's Disease (PD).Brain sciences · 2017Review
- Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson's Symptoms.Frontiers in aging neuroscience · 2017Article
- SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson.Frontiers in aging neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Prior work has shown that functional connectivity between the midbrain and putamen is altered in patients with impairments in the dopamine system. This study examines whether individual differences in midbrain-striatal connectivity are proportional to the integrity of the dopamine system in patients with nigrostriatal dopamine loss (Parkinson's disease and dementia with Lewy bodies). We assessed functional connectivity of the putamen during resting state fMRI and dopamine transporter (DAT) availability in the striatum using 11C-Altropane PET in twenty patients. In line with the hypothesis that functional connectivity between the midbrain and the putamen reflects the integrity of the dopaminergic neurotransmitter system, putamen-midbrain functional connectivity was significantly correlated with striatal DAT availability even after stringent control for effects of head motion. DAT availability did not relate to functional connectivity between the caudate and thalamus/prefrontal areas. As such, resting state functional connectivity in the midbrain-striatal pathway may provide a useful indicator of underlying pathology in patients with nigrostriatal dopamine loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.