Evidence map›Paper›PMID 26137382›Full record

ArticleBiomedical optics express2015

Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.

Melissa M Eberle, Mike S Hsu, Carissa L Rodriguez, Jenny I Szu, Michael C Oliveira, Devin K Binder, B Hyle Park

Abstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melissa M EberleDepartment of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
Mike S HsuDivision of Biomedical Sciences, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
Carissa L RodriguezDepartment of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
Jenny I SzuDivision of Biomedical Sciences, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
Michael C OliveiraDepartment of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
Devin K BinderDivision of Biomedical Sciences, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.
B Hyle ParkDepartment of Bioengineering, University of California, Riverside, 900 University Ave. Riverside, CA 92521, USA.

Funding

Optical Detection of the Pre-seizure StateR01NS081243 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BINDER, DEVIN K · 2013 to 2015
$1.3M
Aquaporin Water Transport, Extracellular Space, and EpilepsyK08NS059674 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BINDER, DEVIN K · 2007 to 2011
$815k
Optical Detection of Neural Activity With Phase Sensitive InterferometryR00EB007241 · NIBIB · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PARK, BORIS HYLE · 2009 to 2011
$724k
NIBIB NIH HHS R00 EB007241NINDS NIH HHS K08 NS059674NINDS NIH HHS R01 NS081243
6 · The paper itself

Abstract

Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.

Indexed as

(100.2960) Image analysis(110.4500) Optical coherence tomography(170.3880) Medical and biological imaging

Identifiers

PMID26137382
PMCPMC4467710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.