ArticleBiomedical optics express2015
Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
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- Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system.Scientific reports · 2024Article
- Single-fiber probes for combined sensing and imaging in biological tissue: recent developments and prospects.Biomedical optics express · 2024Review
- Multimodal imaging needle combining optical coherence tomography and fluorescence for imaging of live breast cancer cells labeled with a fluorescent analog of tamoxifen.Journal of biomedical optics · 2022Article
- Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications.Biosensors · 2022Review
- EndoscopicBiomedical optics express · 2022Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- Use of intra-operative stimulation of brainstem lesion target sites for frameless stereotactic biopsies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.Molecules (Basel, Switzerland) · 2020Article
- Coregistered optical coherence tomography and frequency-encoded multispectral imaging for spectrally sparse color imaging.Journal of biomedical optics · 2019Article
- Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor.Methods and applications in fluorescence · 2019Article
- En-face optical coherence tomography/fluorescence endomicroscopy for minimally invasive imaging using a robotic scanner.Journal of biomedical optics · 2019Article
- High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model.Biomedical optics express · 2018Article
- Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans.Science advances · 2018Article
- 5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy.Biomedical optics express · 2018Article
- Dimension reduction technique using a multilayered descriptor for high-precision classification of ovarian cancer tissue using optical coherence tomography: a feasibility study.Journal of medical imaging (Bellingham, Wash.) · 2017Article
- Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber.Optics letters · 2017Article
- Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular imaging using optical techniques provides insight into disease at the cellular level. In this paper, we report on a novel dual-modality probe capable of performing molecular imaging by combining simultaneous three-dimensional optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may be inserted tens of millimeters into tissue. The MI needle utilizes double-clad fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system and a fluorescence imaging subsystem using an asymmetrical double-clad fiber coupler customized to achieve high fluorescence collection efficiency. We present, to the best of our knowledge, the first dual-modality OCT and fluorescence needle probe with sufficient sensitivity to image fluorescently labeled antibodies. Such probes enable high-resolution molecular imaging deep within tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.