ArticleBiomedical optics express2015
Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Optical performance of minimally invasive brain implants: a simulation and phantom study.Biomedical optics express · 2026Article
- Weighting scheme for robust depth normalization in reflectance time-domain diffuse optical tomography.Journal of biomedical optics · 2026Article
- "hDOS": an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision andJournal of biomedical optics · 2025Article
- Photon transport through the entire adult human head.Neurophotonics · 2025Article
- Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential.Biomedical optics express · 2024Article
- Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector.Journal of biomedical optics · 2023Article
- Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array.Journal of biomedical optics · 2023Article
- Light sheet autofluorescence lifetime imaging with a single photon avalanche diode array.bioRxiv : the preprint server for biology · 2023Article
- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study.Advances in experimental medicine and biology · 2023Article
- High-Speed Time-Domain Diffuse Optical Tomography with a Sensitivity Equation-based Neural Network.IEEE transactions on computational imaging · 2023Article
- Resolution and penetration depth of reflection-mode time-domain near infrared optical tomography using a ToF SPAD camera.Biomedical optics express · 2022Article
- Transcranial optical monitoring for detecting intracranial pressure alterations in children with benign external hydrocephalus: a proof-of-concept study.Neurophotonics · 2022Article
- Estimation of porcine pancreas optical properties in the 600-1100 nm wavelength range for light-based therapies.Scientific reports · 2022Article
- Reconstruction of optical coefficients in turbid media using time-resolved reflectance and calibration-free instrument response functions.Biomedical optics express · 2022Article
- Evaluation of a pipeline for simulation, reconstruction, and classification in ultrasound-aided diffuse optical tomography of breast tumors.Journal of biomedical optics · 2022Article
- 2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics.Biomedical optics express · 2022Article
- Time-domain NIRS system based on supercontinuum light source and multi-wavelength detection: validation for tissue oxygenation studies.Biomedical optics express · 2021Article
- Enhanced diffuse optical tomographic reconstruction using concurrent ultrasound information.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening.Biomedical optics express · 2021Article
- Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow.Biomedical optics express · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light is a powerful tool to non-invasively probe highly scattering media for clinical applications ranging from oncology to neurology, but also for molecular imaging, and quality assessment of food, wood and pharmaceuticals. Here we show that, for a paradigmatic case of diffuse optical imaging, ideal yet realistic time-domain systems yield more than 2-fold higher depth penetration and many decades higher contrast as compared to ideal continuous-wave systems, by adopting a dense source-detector distribution with picosecond time-gating. Towards this aim, we demonstrate the first building block made of a source-detector pair directly embedded into the probe based on a pulsed Vertical-Cavity Surface-Emitting Laser (VCSEL) to allow parallelization for dense coverage, a Silicon Photomultiplier (SiPM) to maximize light harvesting, and a Single-Photon Avalanche Diode (SPAD) to demonstrate the time-gating capability on the basic SiPM element. This paves the way to a dramatic advancement in terms of increased performances, new high impact applications, and availability of devices with orders of magnitude reduction in size and cost for widespread use, including quantitative wearable imaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.