Evidence map›Paper›PMID 26137371›Full record

ArticleBiomedical optics express2015

Dual-modality fiber-based OCT-TPL imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques.

Tianyi Wang, Austin McElroy, David Halaney, Deborah Vela, Edmund Fung, Shafat Hossain, Jennifer Phipps, Bingqing Wang, Biwei Yin, Marc D Feldman and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tianyi WangDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Austin McElroyDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
David HalaneyDivision of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA ; South Texas Veterans Health Care System, San Antonio, Texas 78229, USA.
Deborah VelaTexas Heart Institute, Houston, Texas 77030, USA.
Edmund FungDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Shafat HossainDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Jennifer PhippsDivision of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA.
Bingqing WangDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Biwei YinDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
Marc D FeldmanDivision of Cardiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA ; South Texas Veterans Health Care System, San Antonio, Texas 78229, USA.
Thomas E MilnerDepartment of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, Texas 78712, USA.
The University of Texas at Austin · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas System · US

Funding

PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Detection of plaque based macrophages with lightI01BX000397 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI FELDMAN, MARC DAVID · 2011 to 2013
–
BLRD VA I01 BX000397NHLBI NIH HHS T32 HL007446
6 · The paper itself

Abstract

New optical imaging techniques that provide contrast to study both the anatomy and composition of atherosclerotic plaques can be utilized to better understand the formation, progression and clinical complications of human coronary artery disease. We present a dual-modality fiber-based optical imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques that combines optical coherence tomography (OCT) and two-photon luminescence (TPL) imaging. Experimental results from ex vivo human coronary arteries show that OCT and TPL optical contrast in recorded OCT-TPL images is complimentary and in agreement with histological analysis. Molecular composition (e.g., lipid and oxidized-LDL) detected by TPL imaging can be overlaid onto plaque microstructure depicted by OCT, providing new opportunities for atherosclerotic plaque identification and characterization.

Indexed as

(110.4500) Optical coherence tomography(170.6280) Spectroscopy, fluorescence and luminescence(170.6935) Tissue characterization(190.1900) Diagnostic applications of nonlinear optics(190.4370) Nonlinear optics, fibers

Identifiers

PMID26137371
PMCPMC4467709
OpenAlexW2048823744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.