ReviewTherapeutic advances in chronic disease2015
Atypical femoral fractures and bisphosphonate use: current evidence and clinical implications.
Review in Therapeutic advances in chronic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 86 citations in OpenAlex.
- Complications after intramedullary nailing of diaphyseal femur fractures in a level I trauma center in Finland.OTA international : the open access journal of orthopaedic trauma · 2026Article
- Non-union after bisphosphonate-associated atypical femoral fractures: a review of the current literature.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Atypical Femoral Fractures Induced by Anti-Resorptive Medications.Current osteoporosis reports · 2026Review
- The top 50 cited publications relating to femoral shaft fractures - A bibliometric analysis of the literature.Journal of orthopaedics · 2025Article
- PDGF-BB improves cortical bone quality through restoring the osteogenic microenvironment in the steroid-associated osteonecrosis of rabbits.Journal of orthopaedic translation · 2025Article
- Atypical Femur Fractures-An Analysis of 69 Patients from 15 Years.Journal of clinical medicine · 2025Article
- Static versus dynamic intramedullary nailing for femoral and tibial shaft fractures: a double-blind, randomized clinical trial.Annals of medicine and surgery (2012) · 2025Article
- FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss.Scientific reports · 2025Article
- Alternative Medical Therapy.Indian journal of orthopaedics · 2023Review
- Review
- A Case Report of Oral Bisphosphonate Treatment for Osteoporosis Leading to Atypical Femoral Fracture and Pathologic Mandibular Fracture.The American journal of case reports · 2023Article
- Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics.International journal of molecular sciences · 2023Review
- Article
- The development, incidence and treatment trends of trochanteric fractures in Germany: a cohort study.Journal of orthopaedic surgery and research · 2023Article
- Atypical tibial fracture in breast cancer patient with bone metastasis receiving denosumab therapy: a case report and review of the literature.Journal of medical case reports · 2023Review
- Article
- Case Report - Short-term Bisphosphonate Use Associated Stress Fractures.Journal of orthopaedic case reports · 2022Article
- For Intramedullary Nailing of Femoral Shaft Fractures, Talon Fixation is Helpful to Cope With the Troublesome Distal Locking, But Conventional Distal Locking With Screws Offers a More Stable Construct. Talon Femoral Nail Versus Conventional Femoral NailUlusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats.International journal of molecular sciences · 2022Article
- Health-related quality of life outcomes after surgical treatment of atypical femur fractures: a multicenter retrospective cohort study.JBMR plus · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a disease characterized by a low bone volume and deterioration of the bone quality, which increases the risk of low-energy fractures. Bisphosphonate (BP) treatment increases the bone mass and reduces the risk of fractures in patients with osteoporosis by suppressing bone resorption. In spite of its clinical benefits, the long-term use of BPs has been linked to the occurrence of atypical femoral fractures (AFFs). Although the evidence had been controversial regarding the association between the occurrence of AFFs and BP use, more recent studies with radiographic adjudication have indicated the significant associations between them. However, the pathogenesis of AFFs is not completely understood. The most popular hypothesis has suggested that the suppression of bone turnover by BPs is responsible; however, some recent reports have implied the involvement of pathophysiological alterations of the bone quality and fracture repair process. In this review, we summarize and discuss the epidemiology, risk factors and pathology of AFFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.