ArticleEvolutionary applications2015
Linking genetic and environmental factors in amphibian disease risk.
Article in Evolutionary applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Environment and Host Genetics Drive Infection Outcomes in a Butterfly Host, but Do Not Interact With Each Other.Ecology and evolution · 2026Article
- Amphibians After Disease-Induced Declines: Genetic Insights Into Population Recoveries.Molecular ecology · 2026Article
- Differential Susceptibility May Not Drive Chytridiomycosis Related Declines in Multi-Host Amphibian Communities.Ecology and evolution · 2026Article
- Article
- Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo).Scientific reports · 2024Article
- Chytrid infections exhibit historical spread and contemporary seasonality in a declining stream-breeding frog.Royal Society open science · 2024Article
- Importance of Genetic-Fitness Correlations for the Conservation of Amphibians.Animals : an open access journal from MDPI · 2023Review
- Recovered frog populations coexist with endemic Batrachochytrium dendrobatidis despite load-dependent mortality.Ecological applications : a publication of the Ecological Society of America · 2023Article
- Challenging a host-pathogen paradigm: Susceptibility to chytridiomycosis is decoupled from genetic erosion.Journal of evolutionary biology · 2022Article
- Morphometric study ofEcology and evolution · 2021Article
- Spatiotemporal adaptive evolution of an MHC immune gene in a frog-fungus disease system.Heredity · 2021Article
- Does genetic diversity protect host populations from parasites? A meta-analysis across natural and agricultural systems.Evolution letters · 2021Article
- Evolutionary principles guiding amphibian conservation.Evolutionary applications · 2020Review
- Chytridiomycosis-induced mortality in a threatened anuran.PloS one · 2020Article
- Article
- A review on the conservation genetic studies of Indian amphibians and their implications on developing strategies for conservation.Journal of genetics · 2019Review
- The Influence of Habitat and Phylogeny on the Skin Microbiome of Amphibians in Guatemala and Mexico.Microbial ecology · 2019Article
- Ancestral chytrid pathogen remains hypervirulent following its long coevolution with amphibian hosts.Proceedings. Biological sciences · 2019Article
- Article
- Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations.Immunogenetics · 2019Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central question in evolutionary biology is how interactions between organisms and the environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis (Bd) has caused variable population declines in the lowland leopard frog (Lithobates yavapaiensis); thus, disease has potentially shaped, or been shaped by, host genetic diversity. Environmental factors can also influence both amphibian immunity and Bd virulence, confounding our ability to assess the genetic effects on disease dynamics. Here, we used genetics, pathogen dynamics, and environmental data to characterize L. yavapaiensis populations, estimate migration, and determine relative contributions of genetic and environmental factors in predicting Bd dynamics. We found that the two uninfected populations belonged to a single genetic deme, whereas each infected population was genetically unique. We detected an outlier locus that deviated from neutral expectations and was significantly correlated with mortality within populations. Across populations, only environmental variables predicted infection intensity, whereas environment and genetics predicted infection prevalence, and genetic diversity alone predicted mortality. At one locality with geothermally elevated water temperatures, migration estimates revealed source-sink dynamics that have likely prevented local adaptation. We conclude that integrating genetic and environmental variation among populations provides a better understanding of Bd spatial epidemiology, generating more effective conservation management strategies for mitigating amphibian declines.
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