ArticleEvolutionary applications2015
Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus.
Article in Evolutionary applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Influence of Host and Landscape-Associated Factors in the Infection and Transmission of Pathogens: The Case of Directly Transmitted Virus in Mammals.Veterinary medicine and science · 2025Pooled it
- Co-Circulation of Divergent Strains Supports Vector-Mediated Transmission of Rodent Hepacivirus J (Viruses · 2026Article
- Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony.PLoS pathogens · 2026Article
- Ecological determinants driving orthohantavirus prevalence in small mammals of Europe: a systematic review.One health outlook · 2025Review
- Tropism ofViruses · 2023Article
- Continuous presence of genetically diverse rustrela virus lineages in yellow-necked field mouse reservoir populations in northeastern Germany.Virus evolution · 2023Article
- Risk factors forEpidemiology and infection · 2022Article
- A Bocage Landscape Restricts the Gene Flow of Pest Vole Populations.Life (Basel, Switzerland) · 2022Article
- Host genetic factors associated with the range limit of a European hantavirus.Molecular ecology · 2022Article
- Impact of Landscape on Host-Parasite Genetic Diversity and Distribution Using theMicroorganisms · 2021Article
- Article
- Spatial and Temporal Dynamics and Molecular Evolution ofViruses · 2021Article
- Genetic Diversity ofViruses · 2021Article
- Detection and Genetic Characterization of Puumala Orthohantavirus S-Segment in Areas of France Non-Endemic for Nephropathia Epidemica.Pathogens (Basel, Switzerland) · 2020Article
- Isolation and characterization of new Puumala orthohantavirus strains from Germany.Virus genes · 2020Article
- Assessing Genome-Wide Diversity in European Hantaviruses through Sequence Capture from Natural Host Samples.Viruses · 2020Article
- Spatial and Temporal Evolutionary Patterns in Puumala Orthohantavirus (PUUV) S Segment.Pathogens (Basel, Switzerland) · 2020Article
- Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China.Viruses · 2019Article
- Prediction of the Spatial Origin of Puumala Virus Infections Using L Segment Sequences Derived from a Generic Screening PCR.Viruses · 2019Article
- Analyzing hemorrhagic fever with renal syndrome in Hubei Province, China: a space-time cube-based approach.The Journal of international medical research · 2019Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations, but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.