ReviewEvolutionary applications2015
Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine.
Review in Evolutionary applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Re-evaluation of publicly available gene-expression databases using machine-learning yields a maximum prognostic power in breast cancer.Scientific reports · 2023Article
- Review
- Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection.eLife · 2020Article
- Eco-oncology: Applying ecological principles to understand and manage cancer.Ecology and evolution · 2020Review
- Cancer Ecology and Evolution: Positive interactions and system vulnerability.Current opinion in systems biology · 2019Article
- Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer.EBioMedicine · 2019Article
- Obesity paradox in cancer: Is bigger really better?Evolutionary applications · 2019Article
- Urban environment and cancer in wildlife: available evidence and future research avenues.Proceedings. Biological sciences · 2019Review
- Energy oversupply to tissues: a single mechanism possibly underlying multiple cancer risk factors.Evolution, medicine, and public health · 2019Article
- Cancer: A disease at the crossroads of trade-offs.Evolutionary applications · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 10 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For an increasing number of biologists, cancer is viewed as a dynamic system governed by evolutionary and ecological principles. Throughout most of human history, cancer was an uncommon cause of death and it is generally accepted that common components of modern culture, including increased physiological stresses and caloric intake, favor cancer development. However, the precise mechanisms for this linkage are not well understood. Here, we examine the roles of ecological and physiological disturbances and resource availability on the emergence of cancer in multicellular organisms. We argue that proliferation of 'profiteering phenotypes' is often an emergent property of disturbed, resource-rich environments at all scales of biological organization. We review the evidence for this phenomenon, explore it within the context of malignancy, and discuss how this ecological framework may offer a theoretical background for novel strategies of cancer prevention. This work provides a compelling argument that the traditional separation between medicine and evolutionary ecology remains a fundamental limitation that needs to be overcome if complex processes, such as oncogenesis, are to be completely understood.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.