ArticleThe journal of venomous animals and toxins including tropical diseases2015
Epidemiological characterization and prognostic factors in patients with confirmed cerebral cryptococcosis in central Taiwan.
Article in The journal of venomous animals and toxins including tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Outcomes of acute meningitis according to immunosuppression status: 15-year retrospective cohort.PloS one · 2026Article
- Cryptococcal Meningitis Beyond Immunosuppression: A Case Report in an Immunocompetent Individual.Case reports in infectious diseases · 2026Article
- The clinic-based predictive modeling for prognosis of patients with cryptococcal meningitis.BMC infectious diseases · 2023Article
- Disseminated cryptococcosis with varicella-zoster virus coinfection of idiopathic CD4 + T lymphocytopenia: a case report and literature review.Virology journal · 2022Review
- Article
- Impaired consciousness and decreased glucose concentration of CSF as prognostic factors in immunocompetent patients with cryptococcal meningitis.BMC infectious diseases · 2020Article
- The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: a hospital-based study.BMC geriatrics · 2019Article
- [Early ventricle-atrium shunts for treating cryptococcal meningitis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Prediction of unfavorable outcomes in cryptococcal meningitis: results of the multicenter Infectious Diseases International Research Initiative (ID-IRI) cryptococcal meningitis study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.Nature reviews. Neurology · 2016Review
- A retrospective research of HIV-negative cryptococcal meningoencephalitis patients with acute/subacute onset.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCryptococcal meningitis is a deadly fungal infection. This study aimed to characterize the epidemiology of cerebral cryptococcosis and to define its prognostic factors.
methodsThis cross-sectional study collected clinical information from cryptococcal meningitis patients with confirmed cerebral cryptococcosis from 2006 to 2012 at the Changhua Christian Healthcare System to access prognostic factors.
resultsFifty-nine adult cryptococcal meningitis patients were studied. The incidence at Changhua Christian Healthcare System was approximately 170 episodes per 100,000 patients within the studied period. Forty-one of 59 cryptococcal meningitis patients developed complications. Overall, 12 of 59 patients died, for a three-month mortality rate of 20.3 %. Prognostic factors positively associated with the three-month mortality included age (>55 years), patient delay, prolonged delay by the doctor in administering antifungal agent therapy, duration of intensive care unit stay, chronic lung disease, cryptococcemia, headache, altered mental status, positive blood cultures, and high cerebrospinal fluid opening pressure (≥250 mm H2O).
conclusionsWe strongly recommend early administration of an antifungal agent to each suspected cryptococcal meningitis patient to decrease both the delay by doctors in administering therapy and the mortality risk. Aggressive and supportive care for severe cryptococcal meningitis patients is critical to decrease overall mortality from this infection.
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