ReviewFrontiers in genetics2015
Replication of Structured DNA and its implication in epigenetic stability.
Review in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- DNA synthesis across DNA hairpins by human PrimPol.DNA repair · 2024Article
- Enhancing the diversity of self-replicating structures using active self-adapting mechanisms.Frontiers in genetics · 2022Article
- From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork.International journal of molecular sciences · 2020Review
- Response of Sulfolobus solfataricus Dpo4 polymerase in vitro to a DNA G-quadruplex.Mutagenesis · 2019Article
- Loop permutation affects the topology and stability of G-quadruplexes.Nucleic acids research · 2018Article
- Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis.Cell cycle (Georgetown, Tex.) · 2018Review
- DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress.The Journal of cell biology · 2017Article
- Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability.Nucleic acids research · 2017Article
- Mutational Pressure in Zika Virus: Local ADAR-Editing Areas Associated with Pauses in Translation and Replication.Frontiers in cellular and infection microbiology · 2017Article
- G-quadruplex DNA structures can interfere with uracil glycosylase activity in vitro.Mutagenesis · 2016Article
- Genome-wide discovery of G-quadruplex forming sequences and their functional relevance in plants.Scientific reports · 2016Article
- NALDB: nucleic acid ligand database for small molecules targeting nucleic acid.Database : the journal of biological databases and curation · 2016Article
- Maternal High Fat Diet Affects Offspring's Vitamin K-Dependent Proteins Expression Levels.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA replication is an extremely risky process that cells have to endure in order to correctly duplicate and segregate their genome. This task is particularly sensitive to DNA damage and multiple mechanisms have evolved to protect DNA replication as a block to the replication fork could lead to genomic instability and possibly cell death. The DNA in the genome folds, for the most part, into the canonical B-form but in some instances can form complex secondary structures such as G-quadruplexes (G4). These G rich regions are thermodynamically stable and can constitute an obstacle to DNA and RNA metabolism. The human genome contains more than 350,000 sequences potentially capable to form G-quadruplexes and these structures are involved in a variety of cellular processes such as initiation of DNA replication, telomere maintenance and control of gene expression. Only recently, we started to understand how G4 DNA poses a problem to DNA replication and how its successful bypass requires the coordinated activity of ssDNA binding proteins, helicases and specialized DNA polymerases. Their role in the resolution and replication of structured DNA crucially prevents both genetic and epigenetic instability across the genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.