ArticleFrontiers in microbiology2015
Increased prevalence of carbapenem resistant Enterobacteriaceae in hospital setting due to cross-species transmission of the bla NDM-1 element and clonal spread of progenitor resistant strains.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- A Systematic Review and Meta-analyses of the Clinical Epidemiology of Carbapenem-Resistant Enterobacteriaceae.Antimicrobial agents and chemotherapy · 2018Pooled it
- Carbapenem-resistant Enterobacterales (CRE) acquisition and molecular characterization following colistin monotherapy and colistin-meropenem combination therapy: findings from the AIDA randomized trial.Antimicrobial resistance and infection control · 2025Trial
- Rectal Colonization by Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- Co-occurrence ofFrontiers in cellular and infection microbiology · 2026Article
- Epidemiological and molecular characterisation of carbapenemase-producing Pseudomonas aeruginosa from a tertiary care hospital, India.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- Molecular Screening of Carbapenem-ResistantJournal of clinical medicine · 2023Article
- Within-Host Resistance and Virulence Evolution of a Hypervirulent Carbapenem-ResistantInfection and drug resistance · 2023Article
- Article
- Molecular epidemiology of carbapenem-resistant hypervirulentEmerging microbes & infections · 2022Article
- Molecular characterization and antibiogram of the carbapenemase gene variants in clinical strains of Pseudomonas aeruginosa.Molecular biology reports · 2022Article
- Unraveling the Diversity of Co-Colonization by CPE.Microorganisms · 2022Article
- Clonal spread of carbapenemase-producing Enterobacteriaceae in a region, China.BMC microbiology · 2022Article
- Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.Clinical microbiology reviews · 2022Article
- A rapid method for detecting and distinguishing metallo-β-lactamase-and serine carbapenemase-producingFrontiers in microbiology · 2022Article
- Molecular characterization of NDM-1-producing carbapenem-resistantFrontiers in cellular and infection microbiology · 2022Article
- Dissemination of Carbapenemases (OXA-48, NDM and VIM) ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Epidemiology and Characterization of CTX-M-55-Type Extended-Spectrum β-Lactamase-ProducingMicroorganisms · 2021Article
- Carbapenem-ResistantFrontiers in cellular and infection microbiology · 2021Article
- Characterization of Carbapenem-Resistant Enterobacteriaceae Cultured From Retail Meat Products, Patients, and Porcine Excrement in China.Frontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the transmission characteristics of carbapenem-resistant Enterobacteriaceae (CRE) strains collected from a hospital setting in China, in which consistent emergence of CRE strains were observable during the period of May 2013 to February 2014. Among the 45 CRE isolates tested, 21 (47%) strains were found to harbor the bla NDM-1 element, and the rest of 24 CRE strains were all positive for bla KPC-2. The 21 bla NDM-1-borne strains were found to comprise multiple Enterobacteriaceae species including nine Enterobacter cloacae, three Escherichia coli, three Citrobacter freundii, two Klebsiella pneumoniae, two Klebsiella oxytoca, and two Morganella morganii strains, indicating that cross-species transmission of bla NDM-1 is a common event. Genetic analyses by PFGE and MLST showed that, with the exception of E. coli and E. cloacae, strains belonging to the same species were often genetically unrelated. In addition to bla NDM-1, several CRE strains were also found to harbor the bla KPC-2, bla VIM-1, and bla IMP-4 elements. Conjugations experiments confirmed that the majority of carbapenem resistance determinants were transferable. Taken together, our findings suggest that transmission of mobile resistance elements among members of Enterobacteriaceae and clonal spread of CRE strains may contribute synergistically to a rapid increase in the population of CRE in clinical settings, prompting a need to implement more rigorous infection control measures to arrest such vicious transmission cycle in CRE-prevalent areas.
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