ArticleFrontiers in microbiology2015
Genomic comparison of closely related Giant Viruses supports an accordion-like model of evolution.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 53 citations in OpenAlex.
- Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Widespread genomic islands are hotspots of genome variations and mosaicism in giant viruses.Nature communications · 2026Article
- Vicennial metagenomic time series unveils evolutionary dynamics of giant viruses in a freshwater ecosystem.Nature communications · 2026Article
- Genome-wide Characterization of Non-shared Sequences among Amphora-shaped Giant Viruses.Microbes and environments · 2026Article
- Taxonomic update for the giant algal chloroviruses of the family Phycodnaviridae.Archives of virology · 2025Article
- Investigations into the Diversity and Distribution of tRNA and Phylogenetics of Translation Factors in Amoebozoa-InfectingViruses · 2025Article
- Structural and Evolutionary Analysis of Proteins Endowed with a Nucleotidyltransferase, or Non-canonical Palm, Catalytic Domain.Journal of molecular evolution · 2024Article
- Genomic and biogeographic characterisation of the novel prasinovirus Mantoniella tinhauana virus 1.Environmental microbiology reports · 2024Article
- Gene duplication as a major force driving the genome expansion in some giant viruses.Journal of virology · 2023Article
- Pangenomic Analysis of Nucleo-Cytoplasmic Large DNA Viruses. I: The Phylogenetic Distribution of Conserved Oxygen-Dependent Enzymes Reveals a Capture-Gene Process.Journal of molecular evolution · 2023Article
- Evolution of giant pandoravirus revealed by CRISPR/Cas9.Nature communications · 2023Article
- Cellular and Natural Viral Engineering in Cognition-Based Evolution.Communicative & integrative biology · 2023Review
- Past and present giant viruses diversity explored through permafrost metagenomics.Nature communications · 2022Article
- Functional Genomic Analyses Reveal an Open Pan-genome for the Chloroviruses and a Potential for Genetic Innovation in New Isolates.Journal of virology · 2022Article
- The genomes of nucleocytoplasmic large DNA viruses: viral evolution writ large.Microbial genomics · 2021Review
- Comparative Analysis of Transcriptional Regulation Patterns: Understanding the Gene Expression Profile inPathogens (Basel, Switzerland) · 2021Review
- Article
- Wide spectrum and high frequency of genomic structural variation, including transposable elements, in large double-stranded DNA viruses.Virus evolution · 2020Article
- Chloroviruses.Viruses · 2019Review
- Genomic and metagenomic signatures of giant viruses are ubiquitous in water samples from sewage, inland lake, waste water treatment plant, and municipal water supply in Mumbai, India.Scientific reports · 2019Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome gigantism occurs so far in Phycodnaviridae and Mimiviridae (order Megavirales). Origin and evolution of these Giant Viruses (GVs) remain open questions. Interestingly, availability of a collection of closely related GV genomes enabling genomic comparisons offer the opportunity to better understand the different evolutionary forces acting on these genomes. Whole genome alignment for five groups of viruses belonging to the Mimiviridae and Phycodnaviridae families show that there is no trend of genome expansion or general tendency of genome contraction. Instead, GV genomes accumulated genomic mutations over the time with gene gains compensating the different losses. In addition, each lineage displays specific patterns of genome evolution. Mimiviridae (megaviruses and mimiviruses) and Chlorella Phycodnaviruses evolved mainly by duplications and losses of genes belonging to large paralogous families (including movements of diverse mobiles genetic elements), whereas Micromonas and Ostreococcus Phycodnaviruses derive most of their genetic novelties thought lateral gene transfers. Taken together, these data support an accordion-like model of evolution in which GV genomes have undergone successive steps of gene gain and gene loss, accrediting the hypothesis that genome gigantism appears early, before the diversification of the different GV lineages.
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