ArticleFrontiers in computational neuroscience2015
Computational modeling suggests distinct, location-specific function of norepinephrine in olfactory bulb and piriform cortex.
Article in Frontiers in computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Reinforced Odor Representations in the Anterior Olfactory Nucleus Can Serve as Memory Traces for Conspecifics.eNeuro · 2025Article
- Noradrenergic inputs from the locus coeruleus to anterior piriform cortex and the olfactory bulb modulate olfactory outputs.Nature communications · 2025Article
- Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer's Disease Pathogenesis.Frontiers in cellular neuroscience · 2022Review
- Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats.Cerebral cortex communications · 2021Article
- Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Noradrenergic effects on olfactory perception and learning.Brain research · 2019Review
- Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation.Frontiers in cellular neuroscience · 2018Article
- Stimulation of the Locus Ceruleus Modulates Signal-to-Noise Ratio in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Noradrenergic modulation from the locus coerulus is often associated with the regulation of sensory signal-to-noise ratio. In the olfactory system, noradrenergic modulation affects both bulbar and cortical processing, and has been shown to modulate the detection of low concentration stimuli. We here implemented a computational model of the olfactory bulb and piriform cortex, based on known experimental results, to explore how noradrenergic modulation in the olfactory bulb and piriform cortex interact to regulate odor processing. We show that as predicted by behavioral experiments in our lab, norepinephrine can play a critical role in modulating the detection and associative learning of very low odor concentrations. Our simulations show that bulbar norepinephrine serves to pre-process odor representations to facilitate cortical learning, but not recall. We observe the typical non-uniform dose-response functions described for norepinephrine modulation and show that these are imposed mainly by bulbar, but not cortical processing.
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