Evidence map›Paper›PMID 26136672›Full record

ReviewFrontiers in human neuroscience2015

Possible Mechanisms Underlying the Therapeutic Effects of Transcranial Magnetic Stimulation.

Alexander V Chervyakov, Andrey Yu Chernyavsky, Dmitry O Sinitsyn, Michael A Piradov

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 157 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 12 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04311619 phase1withdrawnnot on this mapstarted 2019, after this paper: background citation

Does Repetitive Transcranial Magnetic Stimulation (rTMS) Induce Synaptic Plasticity?

TypeinterventionalSponsorDavidzon, Guido, M.D.Ran2019 to 2025Enrolled0ConditionsMajor Depressive DisorderArms[11C]UCB-J radiotracer, PET-MR
NCT07518745 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Mapping Transcrnial Magnetic Stimulation (TMS) Responses Within the Brain Using Intracranial Electrophysiological Monitoring Recordings

TypeinterventionalSponsorUniversity of PennsylvaniaRan2025 to 2029Enrolled10ConditionsEEG, TMSArmsSingle Pulse TMS
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 12 syntheses or guidelines pooled it, 368 citations in OpenAlex.

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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alexander V ChervyakovResearch Center of Neurology , Moscow , Russia.
Andrey Yu ChernyavskyMoscow Institute of Physics and Technology, Russian Academy of Sciences , Moscow , Russia ; Faculty of Computational Mathematics and Cybernetics, Moscow State University , Moscow , Russia.
Dmitry O SinitsynResearch Center of Neurology , Moscow , Russia ; Semenov Institute of Chemical Physics, Russian Academy of Sciences , Moscow , Russia.
Michael A PiradovResearch Center of Neurology , Moscow , Russia.
Research Center of Neurology · RULomonosov Moscow State University · RUSemenov Institute of Chemical Physics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is an effective method used to diagnose and treat many neurological disorders. Although repetitive TMS (rTMS) has been used to treat a variety of serious pathological conditions including stroke, depression, Parkinson's disease, epilepsy, pain, and migraines, the pathophysiological mechanisms underlying the effects of long-term TMS remain unclear. In the present review, the effects of rTMS on neurotransmitters and synaptic plasticity are described, including the classic interpretations of TMS effects on synaptic plasticity via long-term potentiation and long-term depression. We also discuss the effects of rTMS on the genetic apparatus of neurons, glial cells, and the prevention of neuronal death. The neurotrophic effects of rTMS on dendritic growth and sprouting and neurotrophic factors are described, including change in brain-derived neurotrophic factor concentration under the influence of rTMS. Also, non-classical effects of TMS related to biophysical effects of magnetic fields are described, including the quantum effects, the magnetic spin effects, genetic magnetoreception, the macromolecular effects of TMS, and the electromagnetic theory of consciousness. Finally, we discuss possible interpretations of TMS effects according to dynamical systems theory. Evidence suggests that a rTMS-induced magnetic field should be considered a separate physical factor that can be impactful at the subatomic level and that rTMS is capable of significantly altering the reactivity of molecules (radicals). It is thought that these factors underlie the therapeutic benefits of therapy with TMS. Future research on these mechanisms will be instrumental to the development of more powerful and reliable TMS treatment protocols.

Indexed as

gene expressionmagnetic fieldmagnetoreceptionsynaptic plasticitytranscranial magnetic stimulation

Identifiers

PMID26136672
PMCPMC4468834
OpenAlexW2123112580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.