ReviewFrontiers in systems neuroscience2015
Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions.
Review in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04369976 (Estimating the Optimal G Level for Training and Rehabilitation on a Short Arm Human Centrifuge), which is not on this map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Estimating the Optimal G Level for Training and Rehabilitation on a Short Arm Human Centrifuge
Who cites it
55 citing papers in PubMed.
- Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study.The Journal of physiology · 2026Trial
- Changes in cerebral oxygen saturation and cerebral blood flow velocity under mild +Gz hypergravity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Graded hypergravity is associated with large-scale reorganization of resting-state cortical networks: EEG evidence from a neurological inactivity phenotype.IBRO neuroscience reports · 2026Article
- The physiology of survival: Space.Experimental physiology · 2026Article
- An eye on long-duration spaceflight: Controversies, countermeasures and challenges.Experimental physiology · 2026Review
- Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest: BRAVE study.Experimental physiology · 2026Article
- Neurophysiological effects of partial gravity on bimanual control: a parabolic flight study.NPJ microgravity · 2026Article
- Hypergravity exposure leads to persistent effects on geotaxis and activity in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- The effect of artificial gravity on the outcome of a two-week resistance vibration exercise programme: BRAVE study.Experimental physiology · 2026Article
- Neuromuscular mechanisms for the fast decline in rate of force development with muscle disuse - a narrative review.The Journal of physiology · 2026Review
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- Are we trapped on Earth: space and accelerated ageing.NPJ microgravity · 2025Review
- A combined individualized cycling exercise and artificial gravity training protocol as a spaceflight deconditioning countermeasure.NPJ microgravity · 2025Article
- Physiological Changes in the Cardiovascular System During Space Flight - Current Countermeasures and Future Vision.Circulation reports · 2025Review
- The effect of combined compression and tactile stimulation on ankle somatosensation in a lunar gravity lower limb load analog.Frontiers in physiology · 2025Article
- Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Frontiers in neurology · 2025Article
- On the nose: nasal neurostimulation as a technology countermeasure for sinonasal congestion in astronauts.Frontiers in physiology · 2025Article
- Impact of Daily Lower-Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest-Induced Orthostatic Intolerance.Journal of the American Heart Association · 2024Article
- Artificial gravity: an effective countermeasure for microgravity-induced headward fluid shift?Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Artificial gravity as a potential countermeasure for Spaceflight Associated Neuro-Ocular Syndrome.Eye (London, England) · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of the experience gained in human space flight since Yuri Gagarin's historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark upon a journey to Mars today, the 6-month exposure to weightlessness en route would leave them considerably debilitated, even with the implementation of the suite of piece-meal countermeasures currently employed. Continuous or intermittent exposure to simulated gravitational states on board the spacecraft while traveling to and from Mars, also known as artificial gravity, has the potential for enhancing adaptation to Mars gravity and re-adaptation to Earth gravity. Many physiological functions are adversely affected by the weightless environment of spaceflight because they are calibrated for normal, Earth's gravity. Hence, the concept of artificial gravity is to provide a broad-spectrum replacement for the gravitational forces that naturally occur on the Earth's surface, thereby avoiding the physiological deconditioning that takes place in weightlessness. Because researchers have long been concerned by the adverse sensorimotor effects that occur in weightlessness as well as in rotating environments, additional study of the complex interactions among sensorimotor and other physiological systems in rotating environments must be undertaken both on Earth and in space before artificial gravity can be implemented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.