ArticleFrontiers in molecular neuroscience2015
Extrinsic and intrinsic regulation of axon regeneration at a crossroads.
Article in Frontiers in molecular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Notch Signaling in Spinal Cord Injury: Mechanistic Insights and Therapeutic Perspectives.Molecular neurobiology · 2026Review
- Stat3 Has a Different Role in Axon Growth During Development Than It Does in Axon Regeneration After Injury.Molecular neurobiology · 2024Article
- Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury.Scientific reports · 2023Article
- Article
- Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.Nature communications · 2022Article
- Mitochondrial function in spinal cord injury and regeneration.Cellular and molecular life sciences : CMLS · 2022Review
- Chemical Signaling Regulates Axon Regeneration via the GPCR-Gqα Pathway inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Overexpression of Reticulon 3 Enhances CNS Axon Regeneration and Functional Recovery after Traumatic Injury.Cells · 2021Article
- Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury.Experimental neurology · 2020Review
- Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury.Cell metabolism · 2020Article
- Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule.Oxidative medicine and cellular longevity · 2020Article
- Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice.Nature communications · 2019Article
- The Tenascin-C-Derived Peptide VSWRAPTA Promotes Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro.Molecular neurobiology · 2019Article
- An injectable heparin-Laponite hydrogel bridge FGF4 for spinal cord injury by stabilizing microtubule and improving mitochondrial function.Theranostics · 2019Article
- Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis.Nature communications · 2018Article
- RhoA activation in axotomy-induced neuronal death.Experimental neurology · 2018Article
- [Review of the regeneration mechanism of complete spinal cord injury].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Review
- A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury.Frontiers in cellular neuroscience · 2017Article
- Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair.Neural regeneration research · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosis, myelin debris and scar tissue that characterize the damaged CNS. Improved axon regeneration and recovery can be elicited by targeting extrinsic factors as well as by boosting neuron-intrinsic growth regulators. Our knowledge of the molecular basis of intrinsic and extrinsic regulators of regeneration has expanded rapidly, resulting in promising new targets to promote repair. Intriguingly certain neuron-intrinsic growth regulators are emerging as promising targets to both stimulate growth and relieve extrinsic inhibition of regeneration. This crossroads between the intrinsic and extrinsic aspects of spinal cord injury is a promising target for effective therapies for this unmet need.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.