Evidence map›Paper›PMID 26136543›Full record

ReviewPhysiology (Bethesda, Md.)2015

Putting the Squeeze on Airway Epithelia.

Jin-Ah Park, Jeffrey J Fredberg, Jeffrey M Drazen

Open access · greenAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Metabolic Reprogramming and ILC2 Plasticity in Obesity-related Asthma.Clinical reviews in allergy & immunology · 2026
    Review
  2. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Global warming risks dehydrating and inflaming human airways.Communications earth & environment · 2025
    Article
  4. The epithelium takes the stage in asthma and inflammatory bowel diseases.Frontiers in cell and developmental biology · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Life (Basel, Switzerland) · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. The Aftermath of Bronchoconstriction.Journal of engineering and science in medical diagnostics and therapy · 2019
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jin-Ah ParkHarvard T. H. Chan School of Public Health, Boston, Massachussetts.
Jeffrey J FredbergHarvard T. H. Chan School of Public Health, Boston, Massachussetts.
Jeffrey M DrazenHarvard T. H. Chan School of Public Health, Boston, Massachussetts jdrazen@nejm.org.
Harvard University · US

Funding

Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
Mechanics of Monolayer MigrationR01HL107561 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2011 to 2015
$3.1M
NHLBI NIH HHS P01 HL120839NHLBI NIH HHS R01 HL107561
6 · The paper itself

Abstract

Asthma is characterized by chronic inflammation, airway hyperresponsiveness, and progressive airway remodeling. The airway epithelium is known to play a critical role in the initiation and perpetuation of these processes. Here, we review how excessive epithelial stress generated by bronchoconstriction is sufficient to induce airway remodeling, even in the absence of inflammatory cells.

Indexed as

Airway RemodelingBronchoconstrictionMechanotransduction, CellularAnimalsAsthmaEpithelial CellsHumansLungPressureRespiratory MucosaStress, Mechanical

Identifiers

PMID26136543
PMCPMC4888965
OpenAlexW2267434778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.