ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Cardiac sympathetic afferent denervation improves cardiac post-ischemic remodeling by maintaining autonomic tone.International journal of cardiology. Heart & vasculature · 2026Article
- [The cannabinoid hyperemesis syndrome-A narrative review].Der Nervenarzt · 2026Review
- Expression and mechanism of TRPV1 channel in prefrontal cortex after acute hypoxic exercise.BMC sports science, medicine & rehabilitation · 2026Article
- Functional crosstalk between the vanilloid and endocannabinoid systems in modulating vascular tone: implications for (neuro)vascular disorder therapy.The journal of headache and pain · 2025Article
- Fetal heart and surroundings: umbilical cord traction triggers sympathetic heart rate surge in fetal lambs in the artificial womb.Frontiers in medicine · 2025Article
- Evidence for enduring cardiac and multiorgan toxicity after repeated exposure to the synthetic cannabinoid JWH-018 in male rats.Toxicology · 2024Article
- Synergistic combinations ofFrontiers in pharmacology · 2024Article
- Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men.Frontiers in physiology · 2023Article
- TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons.eLife · 2022Article
- Systemic application of the transient receptor potential vanilloid-type 4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation.Biology letters · 2022Article
- Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in brown adipose tissue.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Topical Analgesic Containing Methyl Salicylate and L-Menthol Accelerates Heat Loss During Skin Cooling for Exercise-Induced Hyperthermia.Frontiers in physiology · 2022Article
- Chili pepper preference development and its impact on dietary intake: A narrative review.Frontiers in nutrition · 2022Review
- Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia.International journal of molecular sciences · 2021Review
- Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival.Frontiers in pharmacology · 2021Article
- Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals.Molecular metabolism · 2019Article
- TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO₂-Drive to Breathe.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice.Journal of pain research · 2019Article
- TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PMOxidative medicine and cellular longevity · 2019Article
- Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.Frontiers in pharmacology · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also regulate basal body temperature in multiple species from mice to humans. In the present study, we investigated whether TRPV1 modulates basal sympathetic nervous system (SNS) activity. C57BL6/J wild-type (WT) mice and TRPV1 knockout (KO) mice were implanted with radiotelemetry probes for measurement of core body temperature. AMG9810 (50 mg/kg) or vehicle (2% DMSO/5% Tween 80/10 ml/kg saline) was injected intraperitoneally. Adrenoceptor antagonists or vehicle (5 ml/kg saline) was injected subcutaneously. In WT mice, the TRPV1 antagonist, AMG9810, caused significant hyperthermia, associated with increased noradrenaline concentrations in brown adipose tissue. The hyperthermia was significantly attenuated by the β-adrenoceptor antagonist propranolol, the mixed α-/β-adrenoceptor antagonist labetalol, and the α1-adrenoceptor antagonist prazosin. TRPV1 KO mice have a normal basal body temperature, indicative of developmental compensation. d-Amphetamine (potent sympathomimetic) caused hyperthermia in WT mice, which was reduced in TRPV1 KO mice, suggesting a decreased sympathetic drive in KOs. This study provides new evidence that TRPV1 controls thermoregulation upstream of the SNS, providing a potential therapeutic target for sympathetic hyperactivity thermoregulatory disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.